151387-00-7

Basic information

• Product Name: 2,4-DICHLOROQUINOLIN-3-CARBOXALDEHYDE
• Synonyms: 2,4-DICHLOROQUINOLIN-3-CARBOXALDEHYDE;2,4-Dichloroquinoline-3-carboxaldehyde;2,4-dichloroquinoline-3-carbaldehyde
• CAS NO: 151387-00-7
• Molecular Formula: C₁₀H₅Cl₂NO
• Molecular Weight: 226.06
• Mol File: 151387-00-7.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Refractive Index: 1.697
• CAS DataBase Reference: 2,4-DICHLOROQUINOLIN-3-CARBOXALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-DICHLOROQUINOLIN-3-CARBOXALDEHYDE(151387-00-7)
• EPA Substance Registry System: 2,4-DICHLOROQUINOLIN-3-CARBOXALDEHYDE(151387-00-7)

Safety Data

• Hazardous Substances Data: 151387-00-7(Hazardous Substances Data)

Usage

General Description

2,4-Dichloroquinolin-3-carboxaldehyde is a chemical compound with the molecular formula C10H5Cl2NO. It is a derivative of quinoline, and its structure consists of a quinoline ring with two chlorine atoms and an aldehyde group attached at the 3-carbon position. 2,4-DICHLOROQUINOLIN-3-CARBOXALDEHYDE has been studied for its potential biological activities, including its use as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It has also been explored for its role in the development of new materials and chemical reactions. The presence of the chlorine atoms and the aldehyde group in its structure make 2,4-dichloroquinolin-3-carboxaldehyde a versatile building block for the synthesis of various compounds with potential applications in different fields.

InChI:InChI=1/C10H5Cl2NO/c11-9-6-3-1-2-4-8(6)13-10(12)7(9)5-14/h1-5H

Upstream product

• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 1076-59-1 3-phenyl-4H-isoxazol-5-one 
• 68-12-2 N,N-dimethyl-formamide 
• 62-53-3 aniline 
• 703-61-7 2,4-dichloroquinoline 

Downstream Products

• 703-61-7 2,4-dichloroquinoline 

Relevant articles and documents

2-Bromo-4-chlorofuran[2,3-b]quinoline, derivatives thereof, their synthetic methods and application

The invention discloses a full-synthetic method of 2-bromo-4-chlorofuran[2,3-b]quinoline, derivatives of 2-bromo-4-chlorofuran[2,3-b]quinoline, and synthetic method and application of the derivatives.The preparation methods applied herein have mild reaction conditions; reagents used herein are low in toxicity; the raw materials are low in price and easy to attain; after-treatment is convenient; massive enrichment is available. Pharmacological experiments show that most of the compounds herein have good antitumor activity and high stability and are expectedly developable into antitumor drugs.

Imidazole based kinase inhibitors

The present invention provides compounds having Formula I and their use for the treatment of cancer.

A novel rearrangement of 3-arylisoxazol-5(4H)-ones: One-pot synthesis of new 2,4-dichloroquinoline-3-carbaldehydes

Vilsmeier-Haack reaction, using a specific combination of phosphorus oxychloride and dimethylformamide, on 3-arylisoxazol-5(4H)ones 1 resulted in 2,4-dichloroquinoline-3-carbaldehydes 6 as the major products along with other minor products, through a novel rearrangement. Oxidation of 6 with alkaline potassium permanganate gave 2,4-dichloroquinoline-3-carboxylic acids 7. Decarboxylation of 6 and decarboxylation of 7 using aqueous sodium hydroxide yielded 2,4-dichloroquinolines 8. All the compounds were characterised by elemental and spectral analysis.