151390-49-7Relevant academic research and scientific papers
ALKOXYMETHYLATION OF ZINC AND SILYL ENOLATES PREPARED FROM α,α-DIHALO KETONES WITH α-CHLORINATED ETHERS
Shchepin, V. V.,Gladkova, G. E.,Semenova, A. v.
, p. 771 - 773 (2007/10/02)
Zinc enolates prepared from geminal α,α-dihaloalkyl phenyl ketones react with α,α-chlorinated ethers to give products of C- and O-alkoxymethylation.Similar silyl enolates give only C-derivatives: 2-bromo-1-phenyl-2-alkoxymethylbutanones.
Reactions of Trialkylsilyl Trifluoromethanesulfonates, I. - Synthesis of Trialkylsilyl Enol Ethers
Emde, Herbert,Goetz, Andreas,Hofmann, Karin,Simchen, Gerhard
, p. 1643 - 1657 (2007/10/02)
The reactions of the ketones 2,2-bromoketones 6, α,β-unsaturated ketones 8, 1,2-diketones, and aliphatic aldehydes 20 with trialkylsilyl triflates 1 in the presence of triethylamine (4) at room temperature yield the silyl enol ethers 3, 7, 9, 11, and 21.The silylation of the unsymmetrical ketones 12 with 1a/4 runs regioselectively in the thermodynamical sense using 1a/12 in excess and yields the enol ethers 13t.The course of this reaction is discussed briefly.
