151392-13-1

Basic information

• Product Name: N-[4-({5-[(4-methylphenyl)amino]-1,3,4-oxadiazol-2-yl}methoxy)phenyl]acetamide
• CAS NO: 151392-13-1
• Molecular Formula: C₁₈H₁₈N₄O₃
• Molecular Weight: 338.3605
• Mol File: 151392-13-1.mol
• Article Data: 1

Chemical Properties

• Density: 1.307g/cm³
• Refractive Index: 1.649
• CAS DataBase Reference: N-[4-({5-[(4-methylphenyl)amino]-1,3,4-oxadiazol-2-yl}methoxy)phenyl]acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[4-({5-[(4-methylphenyl)amino]-1,3,4-oxadiazol-2-yl}methoxy)phenyl]acetamide(151392-13-1)
• EPA Substance Registry System: N-[4-({5-[(4-methylphenyl)amino]-1,3,4-oxadiazol-2-yl}methoxy)phenyl]acetamide(151392-13-1)

Safety Data

• Hazardous Substances Data: 151392-13-1(Hazardous Substances Data)

Upstream product

• 75129-75-8 N‐(4‐(2‐hydrazinyl‐2‐oxoethoxy)phenyl) acetamide 
• 67202-81-7 ethyl 2-[4-(acetylamino)phenoxy]acetate 
• 103-90-2 4-acetaminophenol 
• 151392-09-5 N¹-<(acetamidophen-4-yl)oxy>acetyl-N⁴-(4-methylphenyl)-3-thiosemicarbazide 

Relevant articles and documents

Anti-inflammatory activity of substituted 1,3,4-oxadiazoles

Various 5-[[(acetamidophen-4-yl)oxy]methyl]-2-(p-substituted phenylamino)- 1,3,4-oxadiazoles (4a-4d) were synthesized by cyclization of the corresponding N1-[[(acetamidophen-4-yl)oxy]acetyl]-N4-(p-substituted phenylamino)-3-thiosemicarbazides (3a-3d). All four of the thiosemicarbazides [250 mg/kg, orally (p.o.)] and the corresponding oxadiazoles (250 mg, p.o.) possessed anti-inflammatory activity. In the Carrageenan-induced edema test in rat paw, the activity ranged from 28 to 47% for 3a-3d and 44 to 63% for 4a-4d, with indomethacin (10 mg/kg, p.o.), used as the standard reference drug, showing 88.5% protection. The compounds (1 mM) were also tested for the inhibition of bovine serum albumin denaturation, and this activity ranged from 27 to 68%. No correlation was seen between the anti-inflammatory activity of 3a-4d and the inhibition of denaturation of bovine serum albumin. The low toxicity of these compounds was reflected by their high approximate 50% lethal dose (LD50) values, ranging from 2000 to 2500 mg/kg.