1514-18-7

Usage

InChI:InChI=1/C13H7FO/c14-11-7-3-6-10-12(11)8-4-1-2-5-9(8)13(10)15/h1-7H

Upstream product

• 50-00-0 formaldehyd 
• 1554-05-8 2-bromo-2’-fluoro-1,1’-biphenyl 
• 1072-85-1 o-fluorobromobenzene 
• 308103-40-4 (2-acetylphenyl)boronic acid 
• 140483-62-1 1-(2′-fluoro-[1,1′-biphenyl]-2-yl)ethanone 
• 98-01-1 furfural 
• 400820-15-7 2'-fluoro-[1,1'-biphenyl]-2-carbonitrile 
• 138642-62-3 2-Cyanophenylboronic acid 
• 348-52-7 1-Fluoro-2-iodobenzene 
• 172732-52-4 o-cyanophenylboronic acid-1,3-propylene glycol ester 
• 4269-15-2 4-aminofluorenone 

Downstream Products

• 7148-56-3 5-Fluor-2-nitro-9-oxo-fluoren 

Relevant academic research and scientific papers

RhI-Catalyzed Intramolecular Carbonylative C?H/C?I Coupling of 2-Iodobiphenyls Using Furfural as a Carbonyl Source

Synthesis of fluoren-9-ones by a Rh-catalyzed intramolecular C?H/C?I carbonylative coupling of 2-iodobiphenyls using furfural as a carbonyl source is presented. The findings indicate that the rate-determining step is not a C?H bond cleavage but, rather, the oxidative addition of the C?I bond to a RhI center.

Pd(0)-catalyzed CO gas-free carbonylation of 2-bromobiphenyls with formaldehyde as a carbonyl surrogate through the cleavage of a CH bond

Paraformaldehyde serves as a carbonyl source in the Pdcatalyzed cyclocarbonylation of 2-bromobiphenyls through the cleavage of a CH bond to afford good yields of fluoren-9-one derivatives. This protocol is also applicable to the reaction of β-bromostyrene, leading to the construction of an indenone framework.

Intramolecular Minisci acylation under silver-free neutral conditions for the synthesis of azafluorenones and fluorenones

Despite its synthetic potential, intramolecular acylation by the Minisci reaction remains unexplored. The development of a new intramolecular Minisci acylation under silver-free neutral conditions providing access to azafluorenones and fluorenones is described. Distinct from the current literature known approaches for Minisci acylation, the report described herein features a method that: (a) avoids the use of silver that is invariably used in Minisci acylation, (b) does not require any acidic conditions for the activation of pyridines, and (c) shows tolerance to functional groups under neutral conditions.

Novel syntheses of fluorenones via nitrile-directed palladium-catalyzed C-H and dual C-H bond activation

Novel procedures for the [Pd]/[Ag]/TFA system catalyzed cascade reactions of nitrile directed remote C-H and dual C-H bond activation with insertion of nitrile were developed, which afforded variously polysubstituted fluorenones in moderate to good yields with tolerance of a wide variety of substrates.