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172732-52-4 Usage

Chemical Properties

White powder

Uses

2-(2-Cyanophenyl)-1,3,2-dioxaborinane is used in the synthesis of AMPA receptor antagonists in the treatment of neurological diseases causing dysfunction of glutamatergic neurotransmission. Also used in the small scale synthesis of Perampanel (P285520), an AMPA receptor antagonist.

Check Digit Verification of cas no

The CAS Registry Mumber 172732-52-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,2,7,3 and 2 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 172732-52:
(8*1)+(7*7)+(6*2)+(5*7)+(4*3)+(3*2)+(2*5)+(1*2)=134
134 % 10 = 4
So 172732-52-4 is a valid CAS Registry Number.
InChI:InChI=1/C10H10BNO2/c12-8-9-4-1-2-5-10(9)11-13-6-3-7-14-11/h1-2,4-5H,3,6-7H2

172732-52-4 Well-known Company Product Price

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  • (Code)Product description
  • CAS number
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  • Detail
  • TCI America

  • (C2993)  2-Cyanophenylboronic Acid 1,3-Propanediol Ester  >97.0%(GC)

  • 172732-52-4

  • 1g

  • 680.00CNY

  • Detail
  • TCI America

  • (C2993)  2-Cyanophenylboronic Acid 1,3-Propanediol Ester  >97.0%(GC)

  • 172732-52-4

  • 5g

  • 2,360.00CNY

  • Detail
  • Aldrich

  • (653934)  2-Cyanophenylboronicacid1,3-propanediolester  96%

  • 172732-52-4

  • 653934-1G

  • 1,788.93CNY

  • Detail

172732-52-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-(1,3,2-Dioxaborinan-2-yl)benzonitrile

1.2 Other means of identification

Product number -
Other names 2-(1,3,2-dioxaborinan-2-yl)benzonitrile

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:172732-52-4 SDS

172732-52-4Synthetic route

2-Cyanophenylboronic acid
138642-62-3

2-Cyanophenylboronic acid

trimethyleneglycol
504-63-2

trimethyleneglycol

o-cyanophenylboronic acid-1,3-propylene glycol ester
172732-52-4

o-cyanophenylboronic acid-1,3-propylene glycol ester

Conditions
ConditionsYield
at 20℃; for 1h;82.4%
In dichloromethane57.2%
In dichloromethane for 20h;57.2%
o-cyanobromobenzene
2042-37-7

o-cyanobromobenzene

o-cyanophenylboronic acid-1,3-propylene glycol ester
172732-52-4

o-cyanophenylboronic acid-1,3-propylene glycol ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: toluene / 0.5 h / 0 - 5 °C / Inert atmosphere
1.2: 1.5 h / 0 - 5 °C
1.3: 0.75 h / 0 - 25 °C
2.1: hydrogenchloride / water / 0.5 h / 0 - 25 °C
3.1: toluene; tetrahydrofuran; Isopropyl acetate / 2 h / 20 - 25 °C
View Scheme
benzonitrile
100-47-0

benzonitrile

o-cyanophenylboronic acid-1,3-propylene glycol ester
172732-52-4

o-cyanophenylboronic acid-1,3-propylene glycol ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: lithium chloride; n-butyllithium / tetrahydrofuran; hexane / -10 °C / Inert atmosphere
1.2: -50 °C / Inert atmosphere
1.3: Inert atmosphere
2.1: 1 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1.1: 2,2,6,6-tetramethyl-piperidine; lithium chloride; n-butyllithium / tetrahydrofuran; hexane / 3 h / -50 - -10 °C / Inert atmosphere
1.2: Inert atmosphere
2.1: 1 h / 20 °C
View Scheme
2-bromoanisole
578-57-4

2-bromoanisole

o-cyanophenylboronic acid-1,3-propylene glycol ester
172732-52-4

o-cyanophenylboronic acid-1,3-propylene glycol ester

2'-methoxy-[1,1'-biphenyl]-2-carbonitrile

2'-methoxy-[1,1'-biphenyl]-2-carbonitrile

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride; potassium phosphate In toluene for 1h; Heating;99%
benzoimidazole
51-17-2

benzoimidazole

o-cyanophenylboronic acid-1,3-propylene glycol ester
172732-52-4

o-cyanophenylboronic acid-1,3-propylene glycol ester

A

salicylonitrile
611-20-1

salicylonitrile

B

benzonitrile
100-47-0

benzonitrile

C

2-(1H-benzo[d]imidazol-1-yl)benzonitrile
25699-93-8

2-(1H-benzo[d]imidazol-1-yl)benzonitrile

Conditions
ConditionsYield
With pyridine; water; copper diacetate In N,N-dimethyl-formamide at 30℃; for 24h; Kinetics; Product distribution; Further Variations:; Reaction partners; amount of water;A n/a
B n/a
C 93%
2-Bromo-m-xylene
576-22-7

2-Bromo-m-xylene

o-cyanophenylboronic acid-1,3-propylene glycol ester
172732-52-4

o-cyanophenylboronic acid-1,3-propylene glycol ester

2',6'-dimethyl-[1,1'-biphenyl]-2-carbonitrile

2',6'-dimethyl-[1,1'-biphenyl]-2-carbonitrile

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride; potassium phosphate In toluene for 1h; Heating;92%
tert-butyl N-(3-(3-iodo-2-oxo-5-(pyrimidin-2-yl)-1,2-dihydropyridin-1-yl)phenyl)carbamate

tert-butyl N-(3-(3-iodo-2-oxo-5-(pyrimidin-2-yl)-1,2-dihydropyridin-1-yl)phenyl)carbamate

o-cyanophenylboronic acid-1,3-propylene glycol ester
172732-52-4

o-cyanophenylboronic acid-1,3-propylene glycol ester

tert-butyl N-(3-(3-(2-cyanophenyl)-2-oxo-5-(pyrimidin-2-yl)-1,2-dihydropyridin-1-yl)phenyl)carbamate

tert-butyl N-(3-(3-(2-cyanophenyl)-2-oxo-5-(pyrimidin-2-yl)-1,2-dihydropyridin-1-yl)phenyl)carbamate

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); caesium carbonate In N,N-dimethyl-formamide at 110℃; for 2h; Inert atmosphere;90%
tert-butyl N-(3-(3-iodo-2-oxo-5-(pyrimidin-2-yl)-1,2-dihydropyridin-1-yl)phenyl)carbamate

tert-butyl N-(3-(3-iodo-2-oxo-5-(pyrimidin-2-yl)-1,2-dihydropyridin-1-yl)phenyl)carbamate

o-cyanophenylboronic acid-1,3-propylene glycol ester
172732-52-4

o-cyanophenylboronic acid-1,3-propylene glycol ester

2-(1,3,2-dioxaboran-2-yl)benzonitrile

2-(1,3,2-dioxaboran-2-yl)benzonitrile

tert-butyl N-(3-(3-(2-cyanophenyl)-2-oxo-5-(pyrimidin-2-yl)-1,2-dihydropyridin-1-yl)phenyl)carbamate

tert-butyl N-(3-(3-(2-cyanophenyl)-2-oxo-5-(pyrimidin-2-yl)-1,2-dihydropyridin-1-yl)phenyl)carbamate

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); caesium carbonate In N,N-dimethyl-formamide at 110℃; for 2h; Inert atmosphere;90%
(E)-2-methylbut-2-enoyl chloride
35660-94-7

(E)-2-methylbut-2-enoyl chloride

o-cyanophenylboronic acid-1,3-propylene glycol ester
172732-52-4

o-cyanophenylboronic acid-1,3-propylene glycol ester

2-[(E)-2-methylbut-2-enoyl]benzonitrile

2-[(E)-2-methylbut-2-enoyl]benzonitrile

Conditions
ConditionsYield
With potassium phosphate; bis-triphenylphosphine-palladium(II) chloride In toluene at 80℃; for 4h;89%
3-iodo-1-(3-dimethylaminophenyl)-5-(pyrimidin-2-yl)pyridin-2(1H)-one

3-iodo-1-(3-dimethylaminophenyl)-5-(pyrimidin-2-yl)pyridin-2(1H)-one

o-cyanophenylboronic acid-1,3-propylene glycol ester
172732-52-4

o-cyanophenylboronic acid-1,3-propylene glycol ester

2-(1-(3-dimethylaminophenyl)-2-oxo-5-(pyrimidin-2-yl)-1,2-dihydropyridin-3-yl)benzonitrile

2-(1-(3-dimethylaminophenyl)-2-oxo-5-(pyrimidin-2-yl)-1,2-dihydropyridin-3-yl)benzonitrile

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); caesium carbonate In N,N-dimethyl-formamide at 115℃; for 0.333333h; Inert atmosphere;89%
With tetrakis(triphenylphosphine) palladium(0); caesium carbonate89%
o-cyanophenylboronic acid-1,3-propylene glycol ester
172732-52-4

o-cyanophenylboronic acid-1,3-propylene glycol ester

1-{3-bromo-4-chloro-5-[1-(R)-fluoropropyl]}phenylpiperazine
172732-49-9

1-{3-bromo-4-chloro-5-[1-(R)-fluoropropyl]}phenylpiperazine

1-{3-(2-cyanophenyl)-4-chloro-5-[1-(R)-fluoropropyl]}phenyl piperazine

1-{3-(2-cyanophenyl)-4-chloro-5-[1-(R)-fluoropropyl]}phenyl piperazine

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride; potassium phosphate In toluene Product distribution; Further Variations:; Reagents;87%
With trans-bis(triphenylphosphine)palladium dichloride; tripotassium phosphate "n" hydrate In toluene at 20℃; for 1h; Suzuki-Miyaura Coupling; Reflux; Inert atmosphere; Large scale;
3-bromo-5-(2-pyridyl)-1-(3-pyridyl)-1,2-dihydropyridin-2-one

3-bromo-5-(2-pyridyl)-1-(3-pyridyl)-1,2-dihydropyridin-2-one

o-cyanophenylboronic acid-1,3-propylene glycol ester
172732-52-4

o-cyanophenylboronic acid-1,3-propylene glycol ester

3-(2-cyanophenyl)-5-(pyridin-2-yl)-1-(pyridin-3-yl)-1,2-dihydropyridin-2-one

3-(2-cyanophenyl)-5-(pyridin-2-yl)-1-(pyridin-3-yl)-1,2-dihydropyridin-2-one

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); caesium carbonate In N,N-dimethyl-formamide at 120℃; for 1h; Suzuki-Miyaura Coupling;84%
potassium phosphate

potassium phosphate

1-(2-trimethylsilyloxyethyl)-4-[3-bromo-4-chloro-5-(1-fluoropropyl)]phenylpiperazine
172732-42-2

1-(2-trimethylsilyloxyethyl)-4-[3-bromo-4-chloro-5-(1-fluoropropyl)]phenylpiperazine

o-cyanophenylboronic acid-1,3-propylene glycol ester
172732-52-4

o-cyanophenylboronic acid-1,3-propylene glycol ester

1-(2-hydroxyethyl)-4-[3-(2-cyanophenyl)-4-chloro-5-(1-fluoropropyl)]phenylpiperazine hydrochloride
172732-18-2

1-(2-hydroxyethyl)-4-[3-(2-cyanophenyl)-4-chloro-5-(1-fluoropropyl)]phenylpiperazine hydrochloride

Conditions
ConditionsYield
With hydrogenchloride; tetrakis(triphenylphosphine)palladium (0) In ethanol; water; N,N-dimethyl-formamide83.9%
3-acetylamino-1-(4-iodo-phenyl)-1H-pyrazole-4-carboxylicacid ethyl ester
1335105-20-8

3-acetylamino-1-(4-iodo-phenyl)-1H-pyrazole-4-carboxylicacid ethyl ester

o-cyanophenylboronic acid-1,3-propylene glycol ester
172732-52-4

o-cyanophenylboronic acid-1,3-propylene glycol ester

3-acetylamino-1-(2'-cyano-biphenyl-4-yl)-1H-pyrazole-4-carboxylic acid ethyl ester
1335105-40-2

3-acetylamino-1-(2'-cyano-biphenyl-4-yl)-1H-pyrazole-4-carboxylic acid ethyl ester

Conditions
ConditionsYield
With potassium phosphate; PdCl2(dppf) In toluene for 2h; Suzuki reaction; Reflux;83%
iodobenzene
591-50-4

iodobenzene

o-cyanophenylboronic acid-1,3-propylene glycol ester
172732-52-4

o-cyanophenylboronic acid-1,3-propylene glycol ester

biphenyl-2-carbonitrile
24973-49-7

biphenyl-2-carbonitrile

Conditions
ConditionsYield
With tripotassium phosphate "n" hydrate; Pd(PPh3)2Cl2 In toluene at 100℃; for 12h; Schlenk technique; Inert atmosphere;77%
1-bromo-2,5-dimethoxybenzene
25245-34-5

1-bromo-2,5-dimethoxybenzene

o-cyanophenylboronic acid-1,3-propylene glycol ester
172732-52-4

o-cyanophenylboronic acid-1,3-propylene glycol ester

2',5'-dimethoxy-[1,1'-biphenyl]-2-carbonitrile
75860-41-2

2',5'-dimethoxy-[1,1'-biphenyl]-2-carbonitrile

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride; potassium phosphate In toluene for 1h; Heating;76%
C16H12BrN3O2
1415212-92-8

C16H12BrN3O2

o-cyanophenylboronic acid-1,3-propylene glycol ester
172732-52-4

o-cyanophenylboronic acid-1,3-propylene glycol ester

2-(1-(6-methoxypyridin-3-yl)-2-oxo-5-(pyridin-2-yl)-1,2-dihydropyridin-3-yl)benzonitrile

2-(1-(6-methoxypyridin-3-yl)-2-oxo-5-(pyridin-2-yl)-1,2-dihydropyridin-3-yl)benzonitrile

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); caesium carbonate In N,N-dimethyl-formamide at 110 - 120℃; for 24h; Inert atmosphere;75%
3-bromo-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridine-2-one
381248-06-2

3-bromo-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridine-2-one

o-cyanophenylboronic acid-1,3-propylene glycol ester
172732-52-4

o-cyanophenylboronic acid-1,3-propylene glycol ester

[14C]-Perampanel
380917-97-5

[14C]-Perampanel

Conditions
ConditionsYield
With caesium carbonate; palladium dichloride In N,N-dimethyl-formamide at 80℃; for 6h; Suzuki-Miyaura Coupling; Inert atmosphere;73%
Stage #1: 3-bromo-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridine-2-one; o-cyanophenylboronic acid-1,3-propylene glycol ester With copper(l) iodide; potassium carbonate; palladium diacetate; triphenylphosphine In 1,2-dimethoxyethane at 70℃; for 4.5h; Heating / reflux;
Stage #2: With ammonia In water at 60℃; for 0.883333h;
With potassium carbonate; palladium diacetate; copper(l) iodide; triphenylphosphine In 1,2-dimethoxyethane at 70℃; for 4.5h; Heating / reflux;
With copper(l) iodide; potassium carbonate; palladium diacetate; triphenylphosphine In 1,2-dimethoxyethane at 70℃; for 4.5h; Heating / reflux;
With tetrakis(triphenylphosphine) palladium(0); triethylamine In dichloromethane at 25 - 30℃; for 12h; Reagent/catalyst; Temperature; Solvent;
C17H10BrN3O
1415212-90-6

C17H10BrN3O

o-cyanophenylboronic acid-1,3-propylene glycol ester
172732-52-4

o-cyanophenylboronic acid-1,3-propylene glycol ester

C24H14N4O
380919-04-0

C24H14N4O

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); caesium carbonate In N,N-dimethyl-formamide at 110 - 120℃; for 24h; Inert atmosphere;73%
potassium phosphate

potassium phosphate

o-cyanophenylboronic acid-1,3-propylene glycol ester
172732-52-4

o-cyanophenylboronic acid-1,3-propylene glycol ester

1-{3-bromo-4-chloro-5-[1-(R)-fluoropropyl]}phenylpiperazine
172732-49-9

1-{3-bromo-4-chloro-5-[1-(R)-fluoropropyl]}phenylpiperazine

1-{3-(2-cyanophenyl)-4-chloro-5-[1-(R)-fluoropropyl]}phenyl piperazine

1-{3-(2-cyanophenyl)-4-chloro-5-[1-(R)-fluoropropyl]}phenyl piperazine

Conditions
ConditionsYield
tetrakis(triphenylphosphine) palladium(0) In water; ethyl acetate; N,N-dimethyl-formamide71%
5-[acetyl-(4-iodo-phenyl)-amino]-1-butyl-1H-pyrazole-4-carboxylic acid ethyl ester
1335105-43-5

5-[acetyl-(4-iodo-phenyl)-amino]-1-butyl-1H-pyrazole-4-carboxylic acid ethyl ester

o-cyanophenylboronic acid-1,3-propylene glycol ester
172732-52-4

o-cyanophenylboronic acid-1,3-propylene glycol ester

5-[acetyl-(2'-cyano-biphenyl-4-yl)-amino]-1-butyl-1H-pyrazole-4-carboxylic acid ethyl ester
1335105-44-6

5-[acetyl-(2'-cyano-biphenyl-4-yl)-amino]-1-butyl-1H-pyrazole-4-carboxylic acid ethyl ester

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride; potassium phosphate In water; toluene for 1.5h; Suzuki reaction; Reflux;71%
benzoyl chloride
98-88-4

benzoyl chloride

o-cyanophenylboronic acid-1,3-propylene glycol ester
172732-52-4

o-cyanophenylboronic acid-1,3-propylene glycol ester

2-cyanobenzophenone
37774-78-0

2-cyanobenzophenone

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride; potassium phosphate In toluene at 110℃; for 4h; Product distribution; Further Variations:; Reagents; Solvents; Suzuki-Miyaura coupling recation;70%
tert-butyl (2-fluoro-5-(3-iodo-2-oxo-5-(pyrimidin-2-yl)pyridin-1(2H)-yl)phenyl)carbamate

tert-butyl (2-fluoro-5-(3-iodo-2-oxo-5-(pyrimidin-2-yl)pyridin-1(2H)-yl)phenyl)carbamate

o-cyanophenylboronic acid-1,3-propylene glycol ester
172732-52-4

o-cyanophenylboronic acid-1,3-propylene glycol ester

tert-butyl (5-(3-(2-cyanophenyl)-2-oxo-5-(pyrimidin-2-yl)pyridin-1(2H)-yl)-2-fluorophenyl)carbamate

tert-butyl (5-(3-(2-cyanophenyl)-2-oxo-5-(pyrimidin-2-yl)pyridin-1(2H)-yl)-2-fluorophenyl)carbamate

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); caesium carbonate In N,N-dimethyl-formamide at 110℃; for 1h; Inert atmosphere;68%
5-(2-pyridyl)-3-bromo-2-methoxypyridine
381248-05-1

5-(2-pyridyl)-3-bromo-2-methoxypyridine

o-cyanophenylboronic acid-1,3-propylene glycol ester
172732-52-4

o-cyanophenylboronic acid-1,3-propylene glycol ester

3-(2-cyanophenyl)-5-(2-pyridyl)-2-methoxypyridine

3-(2-cyanophenyl)-5-(2-pyridyl)-2-methoxypyridine

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); caesium carbonate In N,N-dimethyl-formamide at 140℃; for 5h; Inert atmosphere;66%
2-bromo-4-butylaniline
51605-98-2

2-bromo-4-butylaniline

o-cyanophenylboronic acid-1,3-propylene glycol ester
172732-52-4

o-cyanophenylboronic acid-1,3-propylene glycol ester

2-(n-butyl)-6-aminophenanthridine
946147-28-0

2-(n-butyl)-6-aminophenanthridine

Conditions
ConditionsYield
With potassium carbonate; tetrakis(triphenylphosphine)palladium (0) In ethanol; toluene65.9%
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In ethanol; toluene for 38h; Reflux; Inert atmosphere;65.9%
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In ethanol; toluene for 38h; Reflux; Inert atmosphere;65.9%
3-bromo-1-(3-fluorophenyl)-5-(pyrimidin-2-yl)pyridin-2(1H)-one

3-bromo-1-(3-fluorophenyl)-5-(pyrimidin-2-yl)pyridin-2(1H)-one

o-cyanophenylboronic acid-1,3-propylene glycol ester
172732-52-4

o-cyanophenylboronic acid-1,3-propylene glycol ester

2-(1-(3-fluorophenyl)-2-oxo-5-(pyrimidin-2-yl)-1,2-dihydropyridin-3-yl)benzonitrile

2-(1-(3-fluorophenyl)-2-oxo-5-(pyrimidin-2-yl)-1,2-dihydropyridin-3-yl)benzonitrile

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); caesium carbonate In N,N-dimethyl-formamide at 120℃; for 3h; Inert atmosphere;60%
3-iodo-1-(3-fluorophenyl)-5-(pyrimidin-2-yl)pyridin-2(1H)-one

3-iodo-1-(3-fluorophenyl)-5-(pyrimidin-2-yl)pyridin-2(1H)-one

o-cyanophenylboronic acid-1,3-propylene glycol ester
172732-52-4

o-cyanophenylboronic acid-1,3-propylene glycol ester

2-(1-(3-fluorophenyl)-2-oxo-5-(pyrimidin-2-yl)-1,2-dihydropyridin-3-yl)benzonitrile

2-(1-(3-fluorophenyl)-2-oxo-5-(pyrimidin-2-yl)-1,2-dihydropyridin-3-yl)benzonitrile

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); caesium carbonate60%
With tetrakis(triphenylphosphine) palladium(0); caesium carbonate In N,N-dimethyl-formamide Suzuki-Miyaura Coupling;28%
5-bromo-1-phenyl-3-iodo-1,2-dihydropyridin-2-one

5-bromo-1-phenyl-3-iodo-1,2-dihydropyridin-2-one

o-cyanophenylboronic acid-1,3-propylene glycol ester
172732-52-4

o-cyanophenylboronic acid-1,3-propylene glycol ester

5-bromo-3-(2-cyanophenyl)-1-phenyl-1,2-dihydropyridin-2-one
381233-77-8

5-bromo-3-(2-cyanophenyl)-1-phenyl-1,2-dihydropyridin-2-one

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); caesium carbonate In N,N-dimethyl-formamide at 80℃; for 2h; Inert atmosphere;52%
C15H9BrFN3O
1415212-89-3

C15H9BrFN3O

o-cyanophenylboronic acid-1,3-propylene glycol ester
172732-52-4

o-cyanophenylboronic acid-1,3-propylene glycol ester

3-(2-cyanophenyl)-5-(pyridin-2-yl)-1-(2-fluoropyridin-5-yl)-1,2-dihydropyridin-2-one

3-(2-cyanophenyl)-5-(pyridin-2-yl)-1-(2-fluoropyridin-5-yl)-1,2-dihydropyridin-2-one

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); caesium carbonate In N,N-dimethyl-formamide at 110 - 120℃; for 24h; Inert atmosphere;42%
tert-butyl 3-iodo-2-oxo-5-(pyrimidin-2-yl)pyridine-1(2H)-carboxylate

tert-butyl 3-iodo-2-oxo-5-(pyrimidin-2-yl)pyridine-1(2H)-carboxylate

o-cyanophenylboronic acid-1,3-propylene glycol ester
172732-52-4

o-cyanophenylboronic acid-1,3-propylene glycol ester

2-(2-oxo-5-(pyrimidin-2-yl)-1,2-dihydropyridin-3-yl)benzonitrile

2-(2-oxo-5-(pyrimidin-2-yl)-1,2-dihydropyridin-3-yl)benzonitrile

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); caesium carbonate In N,N-dimethyl-formamide at 110℃; Inert atmosphere;41%
2-bromo-4-n-hexylaniline
946147-25-7

2-bromo-4-n-hexylaniline

o-cyanophenylboronic acid-1,3-propylene glycol ester
172732-52-4

o-cyanophenylboronic acid-1,3-propylene glycol ester

2-(n-hexyl)-6-aminophenanthridine

2-(n-hexyl)-6-aminophenanthridine

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In ethanol; toluene for 20h; Reflux; Inert atmosphere;39.8%
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In ethanol; toluene for 20h; Reflux; Inert atmosphere;39.8%

172732-52-4Relevant articles and documents

Preparation method of o-nitrile phenylboronic acid-1, 3-propylene glycol ester

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Paragraph 0036-0037, (2021/01/29)

The invention discloses a preparation method of o-nitrile phenylboronic acid-1, 3-propylene glycol ester, which belongs to the technical field of organic boric acid chemistry. The method comprises thefollowing steps of starting from o-bromobenzonitrile, carrying out a one-pot reaction with borate/n-butyllithium or metal lithium/boron halide amine, after the reaction is detected to be finished, carrying out acidolysis to obtain 2-nitrile phenylboronic acid, or directly filtering, distilling, adding 1, 3-propylene glycol to form ester, pulping, and purifying to obtain the o-nitrile phenylboronic acid-1, 3-propylene glycol ester. The key point of the process is that the reaction liquid is added into the acid water for quenching after the reaction is finished, so that the condition that the acid water is added into a reaction system to be subjected to an alkaline environment first and then to an acid environment is avoided, the yield is kept stable in different amplification stages, and the process has an industrial amplification prospect. And corresponding boric acid ester can be smoothly obtained by replacing propylene glycol with other glycols.

METAL COMPLEXES OF CYCLOMETALLATED IMIDAZO[1,2-f]PHENANTHRIDINE AND DIIMIDAZO[1,2-A:1',2'-C]QUINAZOLINE LIGANDS AND ISOELECTRONIC AND BENZANNULATED ANALOGS THEREOF

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Paragraph 0258; 0259; 0260; 0261; 0262, (2016/10/07)

The present invention refers to-imidazo [1,2-f] the dee trillion which gets torn phenylphenanthridines and [1,2-a:1 ', 2' -c] quinazoline ligands, or its isoelectronic characteristic and or phosphor including analogue relates to compounds including metal complex. Furthermore, the present invention refers to these compounds including relates organic light emitting diode devices. (by machine translation)

PROCESS FOR THE PREPARATION OF 2-CYANOPHENYLBORONIC ACID AND ESTERS THEREOF

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Paragraph 0061; 0062, (2014/12/09)

The present invention relates to a process for the synthesis of 2-cyanophenylboronic acid and the esters and salts thereof of formula (II), which are intermediates of the synthesis of active pharmaceutical ingredients such as Perampanel or E2040. formula (II): (II).

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