151467-40-2Relevant academic research and scientific papers
Scandium triflate as an efficient and recyclable catalyst for the deprotection of tert-butyl aryl sulfonamides
Mahalingam,Wu, Xiongyu,Wan, Yiqian,Alterman, Mathias
, p. 417 - 425 (2007/10/03)
A mild and efficient method for deprotection of tert-butyl sulfonamide groups utilizing Sc(OTf)3 as deprotecting reagent has been developed. A variety of tert-butyl aryl sulfonamides used under these conditions gave the corresponding primary sulfonamides in high yields. The Lewis acid catalyst could be fully recovered and reused with maintained activity after the reactions. Copyright Taylor & Francis, Inc.
First Reported Nonpeptide AT1 Receptor Agonist (L-162,313) Acts as an AT2 Receptor Agonist in Vivo
Wan, Yiqian,Wallinder, Charlotta,Johansson, Berndt,Holm, Mathias,Mahalingam,Wu, Xiongyu,Botros, Milad,Karlén, Anders,Pettersson, Anders,Nyberg, Fred,F?ndriks, Lars,Hallberg, Anders,Alterman, Mathias
, p. 1536 - 1546 (2007/10/03)
In this investigation, it is demonstrated that the first nonpeptide AT 1 receptor agonist L-162,313 (1), disclosed in 1994, also acts as an agonist at the AT2 receptor. In anesthetized rats, administration of compound 1 intravenously
Boron trichloride as an efficient and selective agent for deprotection of tert-butyl aryl sulfonamides
Wan, Yiqian,Wu, Xiongyu,Kannan, Mahalingam A.,Alterman, Mathias
, p. 4523 - 4525 (2007/10/03)
A fast, mild and selective method for deprotection of tert-butyl aryl sulfonamides utilizing BCl3 as deprotection reagent has been developed. A variety of tert-butyl aryl sulfonamides used under these conditions gave the corresponding primary sulfonamides in high yields. The method does not cleave methoxy groups and prevents incorporation of tert-butyl groups onto electron-rich aromatic rings.
