15148-69-3Relevant academic research and scientific papers
Enantioselective Synthesis of α-Aryl-β-Aminocyclopropane Carboxylic Acid Derivatives via Rh(II)-Catalyzed Cyclopropanation of Vinylsulfonamides with α-Aryldiazoesters
Zhu, Yuqi,Zhou, Ting,Zhang, Hong,He, Jieyin,Li, Hongguang,Lang, Ming,Wang, Jian,Peng, Shiyong
, p. 1074 - 1085 (2022/01/20)
The reaction of vinylsulfonamides with donor–acceptor carbenes derived from α-aryldiazoesters, catalyzed by the tert-butyl glycine-derived dirhodium complex Rh2(S-4-Br-NTTL)4, has been reported. This method provides a variety of α-aryl-β-aminocyclopropane carboxylic acid derivatives bearing one quaternary carbon stereogenic center vicinal to the amino-substituted carbon in high yields with excellent diastereo- and enantioselectivities. Vinylsulfonamides showed complementary advantages over the well-developed vinylamides or vinylcarbamates for this Rh(II)-catalyzed cyclopropanation strategy. Moreover, these conformationally restricted α-aryl-β-aminocyclopropyl carboxylic acid derivatives can be readily incorporated into dipeptides.
Room-temperature palladium(II)-catalyzed N-vinylation of sulfonamides and acylamides with vinyl acetate as vinyl source
Xu, Jun,Fu, Yao,Xiao, Bin,Gong, Tianjun,Guo, Qingxiang
experimental part, p. 5476 - 5479 (2010/10/20)
Room-temperature N-vinylation of various substituted sulfonamides and acylamides with vinyl acetate was achieved for the first time with a palladium/carbene catalyst system. This reaction provides a useful method for synthesis of enamides under mild conditions.
