151576-02-2Relevant academic research and scientific papers
A Novel Synthesis of "Double Headed" Nucleosides via "Reversed" Nucleosides
Kasnar, Biserka,Skaric, Vinko,Klaic, Branimir,Zinic, Mladen
, p. 4997 - 5000 (1993)
The "double headed" nucleosides 10, 11 and 13 bearing pyrimidine or purine bases attached on C-1 and C-5 positions of single ribose unit have been synthesized following a new synthetic strategy.The strategy rests on the introduction of the first nucleobase at C-5 position of the ribose unit giving "reversed" nucleoside and the subsequent attachment of the second base at C-1 position of the ribose, by classical glycosylation reaction.This order of the base attachments gave much better yields on the "double headed" nucleosides then previously known C-1 then C-5 order of attachments.
