151600-50-9Relevant academic research and scientific papers
Microwave assisted enantioselective Michael addition reaction using BINOL-Al-Li catalyst
Narasimhan,Velmathi
, p. 3791 - 3795 (2002)
Enantioselective (S)-BINOL-Al-Li catalyzed Michael reaction of malonates and thiols with cyclic enones are achieved with high enantioselectivity in a remarkably lesser reaction time using microwaves.
Helical foldamer-catalyzed enantioselective 1,4-addition reaction of dialkyl malonates to cyclic enones
Umeno, Tomohiro,Ueda, Atsushi,Doi, Mitsunobu,Kato, Takuma,Oba, Makoto,Tanaka, Masakazu
supporting information, (2019/11/13)
The introduction of a five-membered ring α,α-disubstituted α-amino acid into L-Leu-based heptapeptides preferentially induced right-handed (P) helical structures. Using 5 ～ 20 mol% of a single helical foldamers-catalyst, enantioselective 1,4-addition reactions of dialkyl malonates to cycloalk-2-enones (5 ～ 7 rings) proceeded to give chiral 3-substituted cycloalkanones with 94 ～ 99% ee in moderate chemical yields, regardless of the ring size of substrates.
Highly efficient asymmetric Michael addition reaction of malonates to α,β-unsaturated ketones promoted by a chiral thiourea/PPY dual-catalyst system
Moritaka, Maya,Miyamae, Naomu,Nakano, Keiji,Ichikawa, Yoshiyasu,Kotsuki, Hiyoshizo
, p. 2554 - 2558,5 (2012/12/11)
The enantioselective Michael addition reaction of malonates to α,β-unsaturated ketones is efficiently promoted by a combined dual-catalyst system composed of chiral thiourea and 4-pyrrolidinopyridine (PPY) in toluene. The expected Michael adducts with cyclic and acyclic enones are obtained in excellent yields and with excellent enantioselectivities.
Highly efficient asymmetric Michael addition reaction of malonates to α,β-unsaturated ketones promoted by a chiral thiourea/PPY dual-catalyst system
Moritaka, Maya,Miyamae, Naomu,Nakano, Keiji,Ichikawa, Yoshiyasu,Kotsuki, Hiyoshizo
, p. 2554 - 2558 (2013/01/13)
The enantioselective Michael addition reaction of malonates to α,β-unsaturated ketones is efficiently promoted by a combined dual-catalyst system composed of chiral thiourea and 4-pyrrolidinopyridine (PPY) in toluene. The expected Michael adducts with cyclic and acyclic enones are obtained in excellent yields and with excellent enantioselectivities. Georg Thieme Verlag Stuttgart · New York.
Four hydroxyls are better than two. the use of a chiral lithium salt of 3,3′-bis-methanol-2,2′-binaphthol as a multifunctional catalyst of enantioselective Michael addition reactions
Belokon, Yuri N.,Gugkaeva, Zalina T.,Maleev, Victor I.,Moskalenko, Margarita A.,Tsaloev, Alan T.,Khrustalev, Victor N.,Hakobyan, Karine V.
experimental part, p. 167 - 172 (2011/04/26)
The catalytic performance of the Li salt of (S)- or (R)-3,3′-bis[bis- (phenyl)hydroxymethyl]-2,2′-dihydroxy-dinaphthalene-1,1′ (BIMBOL) in asymmetric Michael additions of malonic acid derivatives and toluedine has been studied. Nitrostyrene and cyclohex-2
Functionalized chiral ionic liquid catalyzed asymmetric SN1 α-alkylation of ketones and aldehydes
Zhang, Long,Cui, Lingyun,Li, Xin,Li, Jiuyuan,Luo, Sanzhong,Cheng, Jin-Pei
experimental part, p. 4876 - 4885 (2010/10/04)
Pyrrolidine-derived functionalized chiral ionic liquids (FCILs) have been found to catalyze asymmetric SN1 α-alkyl-ations of ketones and aldehydes with up to 99% yield, >99:1 dr and 87% ee. The FCIL catalysts enable SN1 α-alkylations
Chemoenzymatic synthesis of 2-oxabicyclo[3.3.1]nonan-3-one enantiomers via microbial reduction by Absidia coerulea AM 93
Olejniczak, Teresa
body text, p. 1 - 10 (2010/10/20)
Microbial enantioselective reduction of (±)-diethyl 2-(3-oxocyclohexyl)malonate (1) has been described. A screening test on twenty-four fungi strains was carried out. Most of the microorganisms preferred bioreduction of (+)-isomer of δ-ketoester (1) to (+
A general organocatalytic enantioselective malonate addition to α,β-unsaturated enones
Wascholowski, Veit,Knudsen, Kristian Rahbek,Mitchell, Claire E. T.,Ley, Steven V.
experimental part, p. 6155 - 6165 (2009/05/27)
A general enantioselective organocatalytic conjugate addition procedure of a variety of malonates to α,β-unsaturated enone systems is presented. The reaction is efficiently catalysed by the pyrrolidinyl tetrazole catalyst 1. Cyclic, acyclic and aromatic e
