22274-75-5

Upstream product

• 996-82-7 sodium diethylmalonate 
• 930-68-7 cyclohexenone 
• 64-17-5 ethanol 
• 105-53-3 diethyl malonate 
• 685-87-0 Diethyl 2-bromomalonate 
• 996-82-7 sodium diethylmalonate 
• 1196977-40-8 C₁₄H₂₀O₅ 
• 108-94-1 cyclohexanone 

Downstream Products

• 137333-34-7 (3-Oxo-cyclohexyl)-acetic Acid 
• 1252759-84-4 C₃₀H₄₀N₂O₅ 
• 151600-50-9 (S)-3-[bis(ethoxycarbonyl)methyl]cyclohexenone 
• 1224876-78-1 (+)-diethyl 2-((1R,3R)-3-hydroxycyclohexyl)malonate 
• 1345614-42-7 diethyl 2-hydroxy-2-(3-oxocyclohexyl)malonate 
• 1405680-38-7 (±)-diethyl 2-(3-(hydroxyimino)cyclohexyl)malonate 
• 1405680-39-8 (±)-diethyl 2-(3-(tosyloxyimino)cyclohexyl)malonate 
• 20053-43-4 α-(3-Methyl-cyclohex-2-en-1-yl)-malonsaeurediethylester 

Relevant academic research and scientific papers

Facile nucleophilic substitution of 3-tert-butyldimethylsilyloxyalk-2-enylphosphonium salts

Phosphoniosilylation of a,β-enones with TBSOTf and triphenylphosphine at 0 °C affords 3-tert-butyldimethylsilyloxyalk-2-enylphosphonium salts, which undergo facile nucleophilic substitution with various nucleophiles to give 3-substituted silyl enol ethers

TRANSITION-METAL CATALYSIS IN MICHAEL ADDITION OF β-DICARBONYLS : TUNING OF THE REACTION CONDITIONS

(2,4-Pentanedionato)copper(I) and bis(2,4-pentanedionato)copper(II) together with boron trifluoride etherate catalyze Michael addition of β-dicarbonyls to cyclohexenone, cyclopentenone, 2-methylcyclopentenone, and 3-thienylidenemalonaldehyde.

Mapping the Surface Groups of Amine-Rich Carbon Dots Enables Covalent Catalysis in Aqueous Media

Carbon nanodots stand as the missing link between the molecular and the nanoscale world, owing to the unique molecular-like behavior emerging from their synthetic precursors. A converging set of analytical and spectroscopic data yields a precise inventory

Cobalt-Catalyzed Regioselective Olefin Isomerization under Kinetic Control

Olefin isomerization is a significant transformation in organic synthesis, which provides a convenient synthetic route for internal olefins and remote functionalization processes. The selectivity of an olefin isomerization process is often thermodynamically controlled. Thus, to achieve selectivity under kinetic control is very challenging. Herein, we report a novel cobalt-catalyzed regioselective olefin isomerization reaction. By taking the advantage of fine-tunable NNP-pincer ligand structures, this catalytic system features high kinetic control of regioselectivity. This mild catalytic system enables the isomerization of 1,1-disubstituted olefins bearing a wide range of functional groups in excellent yields and regioselectivity. The synthetic utility of this transformation was highlighted by the highly selective preparation of a key intermediate for the total synthesis of minfiensine. Moreover, a new strategy was developed to realize the selective monoisomerization of 1-alkenes to 2-alkenes dictated by installing substituents on the γ-position of the double bonds. Mechanistic studies supported that the in situ generated Co-H species underwent migratory insertion of double bond/β-H elimination sequence to afford the isomerization product. The less hindered olefin products were always preferred in this cobalt-catalyzed olefin isomerization due to an effective ligand control of the regioselectivity for the β-H elimination step.

On-water magnetic NiFe2O4 nanoparticle-catalyzed Michael additions of active methylene compounds, aromatic/aliphatic amines, alcohols and thiols to conjugated alkenes

Here, we have demonstrated the Michael addition of active methylene compounds, aromatic/aliphatic amines, thiols and alcohols to conjugated alkenes using magnetic nano-NiFe2O4 as reusable catalyst in water. Nano-NiFe2O4 efficiently catalyzed the formation of C-C and C-X (X = N, S, O etc.) bond through 1,4-addition reactions.

Facile Synthesis of Spirocyclic Lactams from β-Keto Carboxylic Acids

A facile synthesis of spirocyclic lactams starting from β-keto carboxylic acids via a one-pot cascade reaction involving a Curtius rearrangement and an intramolecular nucleophilic addition of the enol carbon to the isocyanate intermediate is reported. The same conditions have also been used for the generation of fused cyclic lactams with similar good yields. The synthetic value of this method has been demonstrated by efficient synthesis of tetracyclic spirolactam 8 and pentacyclic spirolactam 9.

IRAK INHIBITORS AND USES THEREOF

The present invention provides arylo-fused thienopyrimidine compounds, compositions thereof, and methods of using the same.

FLT3 INHIBITORS AND USES THEREOF

The present invention provides methods of using compounds of formula I: or compositions thereof for the inhibition of FLT3, and the treatment of FLT3-mediated disorders.

SUBSTITUTED TETRAHYDROCARBAZOLE AND CARBAZOLE CARBOXAMIDE COMPOUNDS

Disclosed are compounds of Formula (I) wherein: the two dotted lines represent either two single or two double bonds; Q is: R1 is F, Cl, —CN, or —CH3; R2 is Cl or —CH3; R3 is —C(CH3)2OH or —CH2CH2OH; Ra is H or —CH3; each Rb is independently F, Cl, —CH3, and/or —OCH3; and n is zero, 1, or 2. Also disclosed are methods of using such compounds as inhibitors of Bruton's tyrosine kinase (Btk), and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.

Efficient organocatalytic michael addition reaction of βketoesters under high pressure1

The Michael addition reaction of ketoesters was efficiently promoted by a cooperative dual catalyst system composed by DMAP and thiourea A under high-pressure conditions (0.8 GPa) in toluene. The expected relatively congested adducts of 1,5-dicarbonyl com