151766-29-9

Upstream product

• 6956-56-5 2,2-dimethoxy-1-phenylethanone 
• 171735-18-5 acetic acid 2,2-dimethoxy-1-phenylethyl ester 

Downstream Products

• 1099698-46-0 (S)-1-(phenyl)-1,2,2-trimethoxyethane 

Relevant academic research and scientific papers

Asymmetric reduction of α-keto acetals with potassium 9-O-(1,2- isopropylidene-5-deoxy-D-xylofuranosyl)-9-boratabicyclo[3.3.1] nonane. Enantioselective synthesis of α-hydroxy acetals with high optical purities

Asymmetric reduction of α-keto acetals with a chiral borohydride, potassiun 9-O-(1,2-isopropylidene-5-deoxy-α-D-xylofuranosyl)-9- boratabicyclo[3.3.1]nonane in THF at -78°C provided the corresponding α- hydroxy acetals with 87-99% ee.

Enantioselective hydrogenation of α-keto acetals with cinchona modified Pt catalyst

The enantioselective hydrogenation of a variety of α-keto acetals to the corresponding α-hydroxy acetals with Pt catalysts modified with cinchonidine derivatives is described with ees up to 97% and high reaction rates, and the influence of the substrate s

An iron variant of the Noyori hydrogenation catalyst for the asymmetric transfer hydrogenation of ketones

We report the design of a new iron catalyst for the asymmetric transfer hydrogenation of ketones. This type of iron catalyst combines the structural characteristics of the Noyori hydrogenation catalyst (an axially chiral 2,2′-bis(phosphino)-1,1′-binaphthyl fragment and the metal-ligand bifunctional motif) and an ene(amido) group that can activate the iron center. After activation by 8 equivalents of potassiumtert-butoxide, (SA,RP,SS)-7aand (SA,RP,SS)-7bare active but nonenantioselective catalysts for the transfer hydrogenation of acetophenone and α,β-unsaturated aldehydes at room temperature in isopropanol. A maximum turnover number of 14480 was observed for (SA,RP,SS)-7ain the reduction of acetophenone. The right combination of the stereochemistry of the axially chiral 2,2′-bis(phosphino)-1,1′-binaphthyl group and the carbon-centered chiral amine-imine moiety in (SA,RP,RR)-7b′afforded an enantioselective catalyst for the preparation of chiral alcohols with moderate to good yields and a broad functional group tolerance.

Enantiomerically pure α-methoxyaryl acetaldehydes as versatile precursors: a facile chemo-enzymatic methodology for their preparation

A facile and efficient synthesis of optically active α-methoxyaryl acetic acids (up to 95% ee), α-methoxyaryl ethanols (up to 93% ee) and α-methoxyaryl acetonitriles (up to 93% ee) was achieved via Arthrobacter sp. lipase-catalyzed kinetic resolution of masked aldehydes as the key synthons, that is, α-hydroxyaryl acetaldehyde acetals.

Catalytic enantioselective reactions. Part 16. Oxazaborolidine-catalyzed asymmetric borane reduction of α-keto acetals

Asymmetric reductions of α-keto acetals using various oxazaborolidines and borane reagents as catalyst and the hydride source, respectively, were compared. The reduction catalyzed by Corey's CBS reagents with N-phenylamine-borane reagents provided α-hydro

Microbial reduction of 2-keto acetals as biocatalytic approach to the enantioselective synthesis of optically active 2-hydroxy acetals

The reduction of the 2-keto acetals 1a and 1b by means of different microorganisms constitutes the biocatalytic access to optically active (46 to 100% ee) 2-hydroxy acetals, (S)-2a or (R)- and (S)-2b, representative compounds of a class of synthetically useful chiral building blocks.