1519-23-9

Basic information

• Product Name: 2-METHYLBUTANOIC ANHYDRIDE
• Synonyms: 2-METHYLBUTANOIC ANHYDRIDE;2-methylbutyric anhydride;Bis(2-methylbutanoic acid)anhydride;Bis(2-methylbutyric)anhydride;2-methylbutanoyl 2-methylbutanoate;2-methylbutyric acid 2-methylbutanoyl ester
• CAS NO: 1519-23-9
• Molecular Formula: C₁₀H₁₈O₃
• Molecular Weight: 186.25
• EINECS: 216-181-6
• Mol File: 1519-23-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 259.5°Cat760mmHg
• Flash Point: 90°C
• Appearance: /
• Density: 0.955g/cm³
• Vapor Pressure: 0.0129mmHg at 25°C
• Refractive Index: 1.427
• CAS DataBase Reference: 2-METHYLBUTANOIC ANHYDRIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHYLBUTANOIC ANHYDRIDE(1519-23-9)
• EPA Substance Registry System: 2-METHYLBUTANOIC ANHYDRIDE(1519-23-9)

Safety Data

• Hazardous Substances Data: 1519-23-9(Hazardous Substances Data)

Usage

General Description

2-METHYLBUTANOIC ANHYDRIDE, also known as 2-ethylbutyric anhydride, is a chemical compound that belongs to the class of carboxylic acid anhydrides. It is a colorless liquid with a strong, pungent odor and is commonly used as a building block for various organic synthesis processes. This chemical has applications in the manufacturing of pharmaceuticals, fragrances, and polymers. It is important to handle 2-METHYLBUTANOIC ANHYDRIDE with caution, as it can be irritating to the skin, eyes, and respiratory system, and its vapors may cause dizziness and headaches. Proper safety measures and handling protocols should be followed when working with this chemical.

InChI:InChI=1/C10H18O3/c1-5-7(3)9(11)13-10(12)8(4)6-2/h7-8H,5-6H2,1-4H3

Upstream product

• 116-53-0 2-Methylbutanoic acid 
• 75-36-5 acetyl chloride 

Downstream Products

• 25228-78-8 3,3-Dimethyl-N-[3-(2-methyl-butyrylamino)-phenyl]-butyramide 
• 25228-84-6 2-Methyl-N-(3-phenylacetylamino-phenyl)-butyramide 
• 25228-79-9 2-Methyl-N-[3-(2,2,2-trifluoro-acetylamino)-phenyl]-butyramide 
• 938-87-4 2-methyl-1-phenyl-butan-1-one 
• 150058-12-1 ethyl 1-<(2'-cyanobiphenyl-4-yl)methyl>-2-(2-methylpropyl)-1H-benzimidazole-7-carboxylate 
• 25228-76-6 2-Methyl-N-[3-(2-methyl-butyrylamino)-phenyl]-butyramide 

Relevant articles and documents

Optimization by Molecular Fine Tuning of Dihydro-β-agarofuran Sesquiterpenoids as Reversers of P-Glycoprotein-Mediated Multidrug Resistance

P-glycoprotein (P-gp) plays a crucial role in the development of multidrug resistance (MDR), a major obstacle for successful chemotherapy in cancer. Herein, we report on the development of a natural-product-based library of 81 dihydro-β-agarofuran sesquiterpenes (2-82) by optimization of the lead compound 1. The compound library was evaluated for its ability to inhibit P-gp-mediated daunomycin efflux in MDR cells. Selected analogues were further analyzed for their P-gp inhibition constant, intrinsic toxicity, and potency to reverse daunomycin and vinblastine resistances. Analogues 6, 24, 28, 59, and 66 were identified as having higher potency than compound 1 and verapamil, a first-generation P-gp modulator. SAR analysis revealed the size of the aliphatic chains and presence of nitrogen atoms are important structural characteristics to modulate reversal activity. The present study highlights the potential of these analogues as modulators of P-gp mediated MDR in cancer cells.

Synthesis of Analogues of the Carboxyl Protease Inhibitor Pepstatin. Effect of Structure in Subsite P3 on Inhibition of Pepsin

A series of pepstatin analogues having minimum structural requirements for tight-binding inhibition has been synthesized and tested on porcine pepsin.Subtle changes in the geometry and size of side chains at the valine-1 position of pepstatin were found to dramatically affect inhibitor potency as well as the type of kinetic behavior observed.The inhibitors reported here can be grouped into two categories: the more potent inhibitors are slow-binding inhibitors, i.e., exhibit slow, time-dependent inhibition; the weaker inhibitors, with Ki values greater than 10-8M, are not time-dependent inhibitors.A minimum kinetic mechanism is proposed to account for the observed kinetic behavior.