1519-23-9

Usage

Uses

Used in Pharmaceutical Industry:
2-METHYLBUTANOIC ANHYDRIDE is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its reactivity and ability to form esters and other derivatives make it a valuable component in the development of new drugs and medications.
Used in Fragrance Industry:
2-METHYLBUTANOIC ANHYDRIDE is used as a raw material in the production of various fragrances and perfumes. Its unique chemical properties allow it to contribute to the creation of distinct and complex scents, enhancing the sensory experience of the final product.
Used in Polymer Industry:
2-METHYLBUTANOIC ANHYDRIDE is used as a monomer or a building block in the synthesis of polymers. Its ability to react with other monomers and form polymer chains makes it an essential component in the development of new materials with specific properties, such as improved strength, flexibility, or durability.
Safety Precautions:
It is crucial to handle 2-METHYLBUTANOIC ANHYDRIDE with care, as it can be irritating to the skin, eyes, and respiratory system. Its vapors may also cause dizziness and headaches. To ensure the safety of workers and the environment, proper safety measures and handling protocols should be followed when working with this chemical. This includes wearing appropriate personal protective equipment, such as gloves, goggles, and respirators, and working in well-ventilated areas.

InChI:InChI=1/C10H18O3/c1-5-7(3)9(11)13-10(12)8(4)6-2/h7-8H,5-6H2,1-4H3

Upstream product

• 116-53-0 2-Methylbutanoic acid 
• 75-36-5 acetyl chloride 

Downstream Products

• 25228-76-6 2-Methyl-N-[3-(2-methyl-butyrylamino)-phenyl]-butyramide 
• 938-87-4 2-methyl-1-phenyl-butan-1-one 
• 150058-12-1 ethyl 1-<(2'-cyanobiphenyl-4-yl)methyl>-2-(2-methylpropyl)-1H-benzimidazole-7-carboxylate 
• 25228-79-9 2-Methyl-N-[3-(2,2,2-trifluoro-acetylamino)-phenyl]-butyramide 
• 25228-84-6 2-Methyl-N-(3-phenylacetylamino-phenyl)-butyramide 
• 25228-78-8 3,3-Dimethyl-N-[3-(2-methyl-butyrylamino)-phenyl]-butyramide 

Relevant academic research and scientific papers

Optimization by Molecular Fine Tuning of Dihydro-β-agarofuran Sesquiterpenoids as Reversers of P-Glycoprotein-Mediated Multidrug Resistance

P-glycoprotein (P-gp) plays a crucial role in the development of multidrug resistance (MDR), a major obstacle for successful chemotherapy in cancer. Herein, we report on the development of a natural-product-based library of 81 dihydro-β-agarofuran sesquiterpenes (2-82) by optimization of the lead compound 1. The compound library was evaluated for its ability to inhibit P-gp-mediated daunomycin efflux in MDR cells. Selected analogues were further analyzed for their P-gp inhibition constant, intrinsic toxicity, and potency to reverse daunomycin and vinblastine resistances. Analogues 6, 24, 28, 59, and 66 were identified as having higher potency than compound 1 and verapamil, a first-generation P-gp modulator. SAR analysis revealed the size of the aliphatic chains and presence of nitrogen atoms are important structural characteristics to modulate reversal activity. The present study highlights the potential of these analogues as modulators of P-gp mediated MDR in cancer cells.

Friedel-Crafts Reaction of 2-Methylfuran with Saturated and α,β-Unsaturated Acid Anhydrides

2-Methylfuran (5) reacts with the saturated acid anhydrides 16 - 26 in the presence of SnCl4 to give the 2-acyl-5-methylfurans 37 - 47 selectively.The unsaturated anhydrides 27 - 32, however, yield mixtures which only in the case of senecioic acid anhydride (29) contain the respective primary product 48.Subsequent reactions lead to the addition products 55 (from 27) and 56 (from 29), and to (E,Z)-mixtures of their enol esters 57 - 62 which could partially be separated and assigned. - The olfactory properties of 2, 37 - 48, 50, 52, and 53 were investigated.

Synthesis of Analogues of the Carboxyl Protease Inhibitor Pepstatin. Effect of Structure in Subsite P3 on Inhibition of Pepsin

A series of pepstatin analogues having minimum structural requirements for tight-binding inhibition has been synthesized and tested on porcine pepsin.Subtle changes in the geometry and size of side chains at the valine-1 position of pepstatin were found to dramatically affect inhibitor potency as well as the type of kinetic behavior observed.The inhibitors reported here can be grouped into two categories: the more potent inhibitors are slow-binding inhibitors, i.e., exhibit slow, time-dependent inhibition; the weaker inhibitors, with Ki values greater than 10-8M, are not time-dependent inhibitors.A minimum kinetic mechanism is proposed to account for the observed kinetic behavior.