15192-56-0

Upstream product

• 1121-60-4 pyridine-2-carbaldehyde 
• 91-00-9 Benzhydrylamine 

Downstream Products

• 15192-57-1 1,1-diphenyl-N-(pyridin-2-ylmethyl)methanamine 
• 3731-51-9 2-(Aminomethyl)pyridine 
• 183016-40-2 [(Benzhydryl-amino)-pyridin-2-yl-methyl]-phosphonic acid diethyl ester 

Relevant academic research and scientific papers

An unsymmetrical binuclear iminopyridine-iron complex and its catalytic isoprene polymerization

A series of chloride-bridged unsymmetrical mixed Fe(ii)-HS/Fe(ii)-LS binuclear structures has been prepared and characterized. Upon activation with MAO, highly efficient catalytic polymerization of isoprene was achieved, delivering an ultra-high molecular

Controlled isoprene polymerization mediated by iminopyridine-iron (II) acetylacetonate pre-catalysts

A ligand controlled stereoselective polymerization of isoprene has been developed. A series of (aryl/alkyl)-iminopyridine iron (II) acetylacetonate complexes: (aryl?=?Ph Fe1; alkyl?=?CH2Ph Fe2, CH (Ph)2 Fe3, CH (Me)2 Fe4, C (Me)3 Fe5, C (Me)2CH2C(Me)3 Fe6), has been prepared in which steric and electronic substituents systematically modified to investigate their influences for isoprene polymerization. The molecular structure of representative complex Fe2 was confirmed by single crystal X-ray diffraction and, revealed a distorted octahedral geometry at iron center. On treatment with methylaluminoxane (MAO), Fe1–Fe6 displayed low (Fe5 & Fe6) to high activities (Fe1–Fe4) with quantitative monomer conversion (>99%) for isoprene polymerization producing polyisoprene of high molecular weight (up to 2.0?×?105?g/mol) and unimodal molecular weight distribution (1.4–3.3). Specifically, complex Fe2 (alkyl?=?CH2Ph) displayed the highest activity of 7.0?×?106?g (mol of Fe)?1?h?1 with 85% conversion of monomer over run time of 10?min at 25?°C. While, Fe6 catalyzed polyisoprene possessed high content of trans-1,4 unit (up to 87%). Furthermore, the influence of the reaction parameters and the nature of the ligands on the catalytic activities and microstructural properties of the polymer were investigated in detail.

An enantioselective CpRu-catalyzed carroll rearrangement

(Chemical Equation Presented) Simple ligands, catalyst, and conditions: The combination of readily prepared unsymmetrical pyridine-imine ligands and [CpRu(CH3CN)3][PF6] (Cp = C5H 5) affords regio- and

Synthesis and characterization of aminopyridine iron(ii) chloride catalysts for isoprene polymerization: Sterically controlled monomer enchainment

In this study, a series of 2-R-6-(1-(alkylamino)methyl)pyridine-iron complexes [alkyl: (CPh3) Fe1H; (CHPh2) Fe2H; (CHPh2) Fe3Me; (CHMePh) Fe4H; (CH2Ph) Fe5H; (CHMe2) Fe6H; (C6H11) Fe7H; (CH2(4-OMe)Ph) Fe8H; (CH2(4-CF3)Ph) Fe9H; (CH2(2,4,6-Me3)Ph) Fe10H; (CH2Ph) Fe11Me] were synthesized and well characterized by ATR-IR spectroscopy, HRMS spectroscopy and elemental analysis. In addition, Fe3Me, Fe4H, Fe7H and Fe11Me were characterized by X-ray diffraction analysis: Fe3Me and Fe11Me adopted distorted tetrahedral geometries in the solid state while Fe4H and Fe7H were found in dimeric or polymeric forms respectively in which chlorides acted as bridging ligands. The catalytic capacities of these iron complexes were investigated for isoprene polymerization. Upon activation with a MAO cocatalyst, the catalytic activities of complexes varied as a function of the steric and electronic influences of substituents. In general, the catalysts bearing the least steric groups and electron-withdrawing groups exhibited relatively high activities. An outstanding activity of 190.6 × 104 g·mol-1·h-1 was obtained by Fe5H [CH2Ph]. Moreover, changes in the steric hindrance around the metal center showed a notable effect on the selectivity of monomer enchainment. In particular, most of the polymers obtained by these complexes bearing flexible frameworks were in favor of 3,4-enchainment.

Paclitaxel Biosynthesis: Adenylation and Thiolation Domains of an NRPS TycA PheAT Module Produce Various Arylisoserine CoA Thioesters

Structure-activity relationship studies show that the phenylisoserinyl moiety of paclitaxel (Taxol) is largely necessary for the effective anticancer activity. Several paclitaxel analogues with a variant isoserinyl side chain have improved pharmaceutical

The Bronsted Acid-Catalyzed Direct Aza-Darzens Synthesis of N-Alkyl cis-Aziridines

A mild protocol for the synthesis of cis-aziridines is described that employs a catalytic amount of Bronsted acid. Despite the potential for diazo compound decomposition via alkylation or homocoupling upon exposure to a proton source, these pathways are slow relative to [2 + 1] annulation in the presence of a Schiff base, leading to aziridine product. The process uses no metals or reagents that must be removed chromatographically, exhibits rapid turnover rates, and produces only atomic nitrogen as a coproduct. High levels of relative stereocontrol are also possible when forming the Schiff base from a chiral nonracemic aldehyde. Copyright

The acidic cleavage of pyridylmethyl(amino)phosphonates. Formation of the corresponding amines

Hydrolysis of 3-pyridylmethyl(amino)phosphonates by means of 20% aq. hydrochloric acid gave corresponding 3-pyridimethyl(amino)phosphonic acids, as expected. However, hydrolysis of 2- and 4-pyridylmethyl(amino)phosphonates led to decomposition of the phosphonates with a cleavage of C-P bond and formation of the corresponding amines. The leaving phosphorus moiety was identified as phosphoric acid. The scope of the reaction is limited to 2- and 4-pyridylmethyl derivatives of aminophosphonic acids and their esters, as well as to the derivatives possessing similar structure. On the contrary, the basic hydrolysis of 2- and 4-pyridylmethyl(amino)phosphonates led to the corresponding monoalkyl esters of the aminophosphonates, and no cleavage of C-P bond was observed in those cases.

1-aminophosphonic acids and esters bearing heterocyclic moiety. Part 2. 1 pyridine, pyrrole and emidazole derivatives

The benzylic amines (benzylamine, benzhydrylamine and benzyl carbamate) were applied in the synthesis of aminophosphonates derived from pyridine, pyrrole and imidazole. The Schiff bases obtained from corresponding heterocyclic aldehydes and benzylic amines were caused to react with diphenyl phosphorate or dibenzyl phosphonate to form corresponding heterocyclic aminophosphonates in good yields. The N-(benzylamino)-phosphonates were deblocked by catalytic hydrogenolysis. The benzhydryl group from the phosphonates was removed by acidic hydrolysis, and the carbobenzyloxy group from the phosphonates can be easy removed by treatment with a solution of 30% HBr in acetic acid, as well. It was found that during acidic hydrolysis of 2-and 4-pyridylmethylaminophosphonates a rearrangement occurred, combined with a cleavage of C-P bond in the phosphonate molecules and subsequent formation of the corresponding amines.