15197-86-1

Upstream product

• 75-69-4 trichlorofluoromethane 
• 402490-62-4 1-bromo-1-fluoro-2-(4-methoxy-phenyl)-ethylene 
• 201230-82-2 carbon monoxide 
• 71-36-3 butan-1-ol 
• 1608-24-8 3-(2,2-difluoroethenyl)anisole 
• 637-69-4 4-Methoxystyrene 
• 2366-31-6 (Z)-1-bromo-2-fluoroethylene 
• 123-11-5 4-methoxy-benzaldehyde 
• 118268-18-1 C₁₆H₁₈FNO₃S 

Downstream Products

• 1657-53-0 cis-4-methoxystilbene 
• 1694-19-5 E-1-(phenyl)-2-(4'-methoxyphenyl)ethene 
• 107441-84-9 (E)-1-(hex-1-enyl)-4-methoxybenzene 
• 4180-23-8 E-1-(4'-methoxyphenyl)prop-1-ene 
• 131161-71-2 (Z)-1-(2-cyclopropylvinyl)-4-methoxybenzene 
• 131161-69-8 (E)-1-(2-cyclopropylvinyl)-4-methoxybenzene 
• 103786-20-5 (E)-1-methoxy-4-(3-methyl-but-1-en-1-yl)benzene 
• 79958-53-5 (E)-1-(3,3-dimethylbut-1-en-1-yl)-4-methoxybenzene 
• 149777-83-3 2-[(E)-2-(4-methoxyphenyl)ethenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 

Relevant academic research and scientific papers

Photoredox-Coupled F-Nucleophilic Addition: Allylation of gem-Difluoroalkenes

A novel strategy for the expedient construction of CF3-embeded tertiary/quarternary carbon centers was developed by taking advantage of photoredox catalysis. Thanks to a key step of single-electron oxidation, electron-rich gem-difluoroalkenes, which otherwise are essentially reluctant towards F-nucleoplilic addition, now readily participate in this fluoroallylation reaction. Furthermore, this strategy provides an elegant example for the generation, as well as functionalization, of α-CF3-substituted benzylic radical intermediates using cheap and readily available starting materials.

METATHESIS CATALYSTS AND METHODS THEREOF

The present application provides, among other things, compounds and methods for metathesis reactions. In some embodiments, the present disclosure provides methods for preparing alkenyl halide with regioselectivity and/or stereoselectivity. In some embodim

Synthesis of monofluoroalkenes through selective hydrodefluorination of gem-difluoroalkenes with Red-Al

A novel and practical approach for the selective hydrodefluorination of gem-difluoroalkenes using Red-Al as a reductant at room temperature in CH2Cl2 without any additional base and metal catalyst was reported. Various monofluoroalkenes were obtained in moderate to high yields with good E-selectivity.

Stereoselective nucleophilic fluoromethylation of aryl ketones: Dynamic kinetic resolution of chiral α-fluoro carbanions

Although many methods are available for the synthesis of optically enriched monofluoromethyl secondary alcohols, synthesizing optically enriched monofluoromethyl tertiary alcohols remains a challenge. An efficient and easy-to-handle nucleophilic fluoromethylation protocol was developed. The current monofluoromethylation showed much higher facial selectivity than the corresponding difluoromethylation and proceeded via a different type of transition state. Excellent stereoselective control at the fluorinated carbon chiral center was found, an effect believed to be facilitated by the dynamic kinetic resolution of the chiral α-fluoro carbanions. Fluoromethyl fix: An efficient and easy-to-handle protocol for the stereoselective synthesis of optically pure monofluoromethyl tertiary alcohols was developed, which showed higher facial selectivity than the corresponding difluoromethylation and proceeded via a different type of transition state. Stereoselective control at the fluorinated carbon chiral center is believed to be facilitated by the dynamic kinetic resolution of the chiral α-fluoro carbanions. Copyright

Stereospecific preparation of symmetrical (1Z, 3Z)- and (1E, 3E)-2,3-difluoro-1,4-disubstituted-buta-1,3-dienes from 1-bromo-1-fluoroalkenes

A straightforward method to prepare symmetrical (1Z, 3Z)- and (1E, 3E)-2,3-difluoro-1,4-disubstituted-buta-1,3-dienes is described. High E/Z ratio 1-bromo-1-fluoroalkenes, prepared by isomerization from the E/Z ≈ 1:1 isomeric mixtures, reacted with Busub

Highly stereoselective synthesis of (E)- and (Z)-α-fluoro-α, β-unsaturated esters and (E)- and (Z)-α-fluoro-α,β- unsaturated amides from 1-bromo-1-fluoroalkenes via palladium-catalyzed carbonylation reactions

The highly stereoselective synthesis of (E)- and (Z)-α-fluoro- α,β-unsaturated esters and (E)- and (Z)-α-fluoro-α, β-unsaturated amides is described. 1-Bromo-1-fluoroalkenes (E/Z ≈ 1:1), which are readily available starting materials, have been found to i

Kinetic separation methodology for the stereoselective synthesis of (E)- and (Z)-alpha-fluoro-alpha,beta-unsaturated esters via the palladium-catalyzed carboalkoxylation of 1-bromo-1-fluoroalkenes.

[reaction: see text] Methodology for the stereoselective preparation of both (E)- and (Z)-alpha-fluoro-alpha,beta-unsaturated esters is described. 1-Bromo-1-fluoroalkenes (E/Z approximate 1:1) can be isomerized to high E/Z ratio mixtures, which participat

α-FLUOROMETHYL-N-METHYL-PHENYLSULPHOXIMINE: A NEW FLUOROMETHYLENATION REAGENT

Treatment of aldehydes or ketones with the anion derived from α-fluoromethyl-N-methyl-phenylsulphoximine produces adducts which afford fluoro-olefins on reductive elimination.