151992-80-2

Upstream product

• 151992-79-9 tert-butyl (methyl 2,3-di-O-benzyl-4-O-p-methoxybenzyl-β-D-glucopyranosid)uronate 
• 152141-84-9 methyl 2,3-di-O-benzyl-4,6-O-(4-methoxybenzylidene)-β-D-glucopyranoside 
• 151992-78-8 methyl 2,3-di-O-benzyl-4-O-p-methoxybenzyl-β-D-glucopyranoside 
• 100-39-0 benzyl bromide 
• 709-50-2 methyl beta-D-glucopyranoside 
• 75-65-0 tert-butyl alcohol 

Downstream Products

• 162552-85-4 Methyl O-(2-azido-3,6-di-O-benzyl-2-deoxy-α-D-glucopyranosyl)-(1->4)-O-tert-butyl 2,3-di-O-benzyl-β-D-glucopyranoside)uronate 
• 162552-86-5 Methyl O-(2-azido-3,6-di-O-benzyl-2-deoxy-β-D-glucopyranosyl)-(1->4)-O-tert-butyl 2,3-di-O-benzyl-β-D-glucopyranoside)uronate 
• 151992-81-3 Methyl O-(methyl 2,3,4-tri-O-acetyl-α-L-idopyranosyluronate)-(1->4)-O-(2-azido-3,6-di-O-benzyl-2-deoxy-α-D-glucopyranosyl)-(1->4)-O-(tert-butyl 2,3-di-O-benzyl-β-D-glucopyranosid)uronate 

Relevant academic research and scientific papers

Synthesis of the methyl glycosides of a tri- and a tetra-saccharide related to heparin and heparan sulphate

The methyl glycoside of a tetrasaccharide isolated from heparin, methyl O-(α-L-idopyranosyluronic acid)-(1 → 4)-O-(2-acetamido-2-deoxy-α-D-glucopyranosyl)-(1 → 4)-O-(β-D-glucopyranosyluronic acid)-(1 → 3)-O-β-D-galactopyranoside disodium salt and a trisaccharide derivative thereof, methyl O-(α-L-idopyranosyluronic acid)-(1 → 4)-O-(2-acetamido-2-deoxy-α-D-glucopyranosyl)-(1 → 4)-O-β-D-glucopyranosyluronic acid disodium salt, were synthesized using a block-type strategy. A suitable protected disaccharide block of iduronic acid and glucosamine (IdoA-GlcN) was used as a key intermediate for the syntheses and was glycosidated with a protected galactose derivative and a disaccharide block of glucuronic acid and galactose (GlcA-Gal) to give tri- and tetra-saccharide derivatives, respectively. Deprotection gave the target compounds. The methyl glycoside of a tetrasaccharide isolated from heparin, disodium salt and a trisaccharide derivative thereof, were synthesized using a block-type strategy. A suitable protected disaccharide block of iduronic acid and glucosamine (IdoA-GlcN) was used as a key intermediate for the syntheses and was glycosidated with a protected galactose derivative and a disaccharide block of glucuronic acid and galactose (GlcA-Gal) to give tri-and tetra-saccharide derivatives, respectively. Deprotection gave the target compounds.