15205-19-3

Upstream product

• 75692-62-5 (C₆H₃Cl₂-2,6)CH=N-CH₃ 
• 83-38-5 2,6-dichlorobenzaldehyde 
• 20443-98-5 2,6-Dichlorobenzyl bromide 
• 74-89-5 methylamine 

Downstream Products

• 956234-44-9 2-(6-{2-[(2,6-dichlorobenzyl)(methyl)amino]ethoxy}hexyl)-1H-isoindole-1,3(2H)-dione 
• 956235-87-3 8-(benzyloxy)-5-{1-{[tert-butyl(dimethyl)silyl]oxy}-2-[(6-{2-[(2,6-dichlorobenzyl)(methyl)amino]ethoxy}hexyl)amino]ethyl}quinolin-2(1H)-one 
• 956234-84-7 N-(2,6-dichlorobenzyl)-5-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-N,2,2,3,3-pentamethyl-4,14-dioxa-7-aza-3-silaheptadecan-17-amine 
• 956235-86-2 N-(2,6-dichlorobenzyl)-5-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-N,2,2,3,3-pentamethyl-4,14-dioxa-7-aza-3-silahexadecan-16-amine 
• 956234-85-8 2-[(6-{3-[(2,6-dichlorobenzyl)(methyl)amino]propoxy}hexyl)amino]-1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)ethanol 
• 956234-48-3 C₂₈H₄₀Cl₂N₂O₄ 
• 956234-82-5 {3-[(6-aminohexyl)oxy]propyl}(2,6-dichlorobenzyl)methylamine 
• 956234-45-0 6-{2-[(2,6-dichlorobenzyl)(methyl)amino]ethoxy}hexan-1-amine 
• 956234-81-4 2-(6-{3-[(2,6-dichlorobenzyl)(methyl)amino]propoxy}hexyl)-1H-isoindole-1,3(2H)-dione 
• 25676-11-3 (2,6-Dichloro-benzyl)-methyl-dithiocarbamic acid 2,4-dinitro-phenyl ester 

Relevant academic research and scientific papers

DERIVATIVES OF 4-(2-AMINO-1-HYDROXIETHYL)PHENOL AS AGONISTS OF THE β2 ADRENERGIC RECEPTOR

This invention is directed to compounds of formula (I): to pharmaceutical compositions comprising them; to combination products comprising them; and to their use in therapy.

TACHYKININ RECEPTOR ANTAGONISTS

The present invention relates to selective NK-1 receptor antagonists of Formula (I) or a pharmaceutically acceptable salt thereof, for the treatment of disorders associated with an excess of tachykinins.

Benzylamines: Synthesis and evaluation of antimycobacterial properties

The synthesis of benzylamines with various N-alkyl chains and substituents in the aromatic system as well as their evaluation on Mycobacterium tuberculosis H 37 Ra are described. The most active compounds in this test, N-methyl-3-chlorobenzylamine (MIC 10.2 μg/mL), N-methyl-3,5-dichlorobenzylamine (93, MIC 10.2 μg/mL), and N-butyl-3,5-difluorobenzylamine (MIC 6.4 μg/mL), also exhibited a marked inhibitory effect on Mycobacterium marinum and Mycobacterium lufu used for the determination of antileprotic properties. The combination of 93 with aminosalicylic acid, streptomycin, or dapsone exert marked supra-additive effects on M. tuberculosis H 37 Ra.