15208-43-2

Upstream product

• 15208-42-1 2-benzothiazol-2-yl-2,2-difluoro-acetamide 
• 381-73-7 Difluoroacetic acid 
• 137-07-5 2-amino-benzenethiol 
• 615-20-3 2-chlorobenzo[d][1,3]thiazole 
• 65864-64-4 trimethyl(difluoromethyl)silane 
• 7144-49-2 2-methanesulfonylbenzothiazole 
• 615-22-5 2-methylmercaptobenzothiazole 
• 2516-40-7 2-bromo-1,3-benzothiazole 
• 1511-62-2 bromodifluoromethane 
• 15206-62-9 4-benzothiazol-2-yl-2,2,3,3,4,4-hexafluoro-butyric acid 
• 15091-16-4 4-benzothiazol-2-yl-2,2,3,3,4,4-hexafluoro-butyryl azide 
• 15091-12-0 4-benzothiazol-2-yl-2,2,3,3,4,4-hexafluoro-butyryl chloride 
• 15090-54-7 3-benzothiazol-2-yl-2,2,3,3-tetrafluoro-propionyl azide 
• 15091-17-5 2-(1,1,2,2,3,3-hexafluoro-3-isocyanato-propyl)-benzothiazole 

Downstream Products

• 939773-92-9 2-difluorophenoxymethylbenzothiazole 

Relevant academic research and scientific papers

Divergent S- And C-Difluoromethylation of 2-Substituted Benzothiazoles

Two unprecedented and complementary synthetic strategies for S- and C-difluoromethylation of 2-substituted benzothiazoles have been developed by taking advantage of the remarkably different reactivity of CF2H- and 2-PySO2CF2- nucleophiles. A variety of structurally diverse difluoromethyl 2-isocyanophenyl sulfides and 2-difluoromethylated benzothiazoles were synthesized with these two new synthetic protocols.

Silver-Enabled General Radical Difluoromethylation Reaction with TMSCF2H

A silver-mediated oxidative difluoromethylation of styrenes and vinyl trifluoroborates with TMSCF2H is reported for the first time. This method enables direct and facile access to CF2H-alkenes from abundant alkenes with excellent functional-group compatibility. Moreover, this Ag/TMSCF2H protocol could further enable a series of radical difluoromethylation reactions of a wide array of substrates, offering a generic and complementary platform for the construction of diversified C?CF2H bonds.

Metallaphotoredox Difluoromethylation of Aryl Bromides

Herein, we report a convenient and broadly applicable strategy for the difluoromethylation of aryl bromides by metallaphotoredox catalysis. Bromodifluoromethane, a simple and commercially available alkyl halide, is harnessed as an effective source of difluoromethyl radical by silyl-radical-mediated halogen abstraction. The merger of this fluoroalkyl electrophile activation pathway with a dual nickel/photoredox catalytic platform enables the difluoromethylation of a diverse array of aryl and heteroaryl bromides under mild conditions. The utility of this procedure is showcased in the late-stage functionalization of several drug analogues.

Process for production of DFMB derivatives

A process for the production of a compound of formula (III) which comprises a step of reacting a compound of formula (I) with an excess amount of a compound of formula (II) in absence of aromatic solvent, wherein n is 0, 1, 2, 3 or 4; X is NH, O or S; eac

PROCESS FOR PRODUCTION OF DFMB DERIVATIVES

Disclosed is a process for the production of a compound of formula (ΙΠ). The process comprises a step of reacting a compound of formula (I) with an excess amount of a compound of formula (II) in absence of aromatic solvent:wherein - n is 0 1, 2, 3 or 4; - X is NH, O or S; - each R] group may be the same or different, and is independently selected from the group consisting of hydrogen, hydroxyl, alkoxy, alkyl, carbonyl, carboxyl, carboxylic acid ester groups, amido, cyano, halogenated aliphatic, nitro, or amino groups; - R2 group is selected from the group consisting of hydroxyl, CI, F, Br, amino or alkoxy.

One-pot synthesis of 2-trifluoromethyl and 2-difluoromethyl substituted benzo-1,3-diazoles

2-Trifluoromethyl and 2-difluoromethyl substituted benzimidazole, benzoxazole and benzothiazole derivatives were efficiently prepared through a one-pot reaction of trifluoroacetic acid and difluoroacetic acid, respectively, with commercially available o-p