939773-92-9Relevant academic research and scientific papers
A facile preparation of 2-bromodifluoromethyl benzo-1,3-diazoles and its application in the synthesis of gem-difluoromethylene linked aryl ether compounds
Jiang, Haizhen,Yuan, Shijie,Cai, Yeshan,Wan, Wen,Zhu, Shizheng,Hao, Jian
, p. 167 - 170 (2012/02/04)
A facile preparation of 2-bromodifluoromethyl benzo-1,3-diazoles as novel CF2Br-containing heterocyclic building blocks has been developed through a one-pot process of reaction of 2-OH, 2-SH, or 2-NH2 substituted aniline with bromodifluoroacetic acid in the presence of 3 molar equivalents of CBr4 and Ph3P in refluxing toluene. 2-Bromodifluoromethyl benzo-1,3-thiazole (2b) was successfully utilized in the preparation of gem-difluoromethylene linked aryl ether compounds through the reaction with phenolates or thiophenolate in DMF in good yields.
One-pot synthesis of 2-trifluoromethyl and 2-difluoromethyl substituted benzo-1,3-diazoles
Ge, Fenglian,Wang, Zengxue,Wan, Wen,Lu, Wencong,Hao, Jian
, p. 3251 - 3254 (2008/02/02)
2-Trifluoromethyl and 2-difluoromethyl substituted benzimidazole, benzoxazole and benzothiazole derivatives were efficiently prepared through a one-pot reaction of trifluoroacetic acid and difluoroacetic acid, respectively, with commercially available o-p
