1521-60-4Relevant articles and documents
Enantiospecific Synthesis of Nepetalactones by One-Step Oxidative NHC Catalysis
Harnying, Wacharee,Neud?rfl, J?rg-M.,Berkessel, Albrecht
supporting information, p. 386 - 390 (2020/02/04)
An efficient oxidative NHC-catalyzed one-step transformation of (S)-or (R)-8-oxocitronellal to nepetalactone (NL) in enantio- A nd diastereomerically pure form has been developed. Several new and "easy to make" N-Mes-or N-Dipp-substituted 1,2,4-triazolium salts carrying nitroaromatic groups on N1 were synthesized and evaluated as precatalysts in combination with base and stoichiometric organic oxidant. Under optimized conditions, NLs are accessible in very good yields and diastereomerically pure under mild conditions. The oxidant used could be recovered and recycled under operationally simple conditions.
TETRAHYDROISOQUINOLINE COMPOUND AND MEDICINAL USE THEREOF
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Page/Page column 20, (2010/11/28)
The present invention provide a tetrahydroisoquinoline compound having a superior ACAT-inhibitory activity and/or anti-oxidation action, particularly, novel compound represented by the formula (I) (wherein each symbol is as described in the specification) and a pharmaceutically acceptable salt thereof.