5096-21-9

Basic information

• Product Name: N-(2,4,6-Trimethylphenyl)acetamide
• Synonyms: Acetomesidide;N-(2,4,6-Trimethylphenyl)acetamide;N-mesitylacetamide
• CAS NO: 5096-21-9
• Molecular Formula: C₁₁H₁₅NO
• Molecular Weight: 177.27
• Mol File: 5096-21-9.mol
• Article Data: 18

Chemical Properties

• Melting Point: 216.5°C
• Boiling Point: 309.18°C (rough estimate)
• Flash Point: 170.1°C
• Appearance: /
• Density: 1.0290 (rough estimate)
• Vapor Pressure: 0.00197mmHg at 25°C
• Refractive Index: 1.5480 (estimate)
• CAS DataBase Reference: N-(2,4,6-Trimethylphenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2,4,6-Trimethylphenyl)acetamide(5096-21-9)
• EPA Substance Registry System: N-(2,4,6-Trimethylphenyl)acetamide(5096-21-9)

Safety Data

• Hazardous Substances Data: 5096-21-9(Hazardous Substances Data)

Usage

General Description

N-(2,4,6-Trimethylphenyl)acetamide, also known as acetaminomal, is a chemical compound that is commonly used as an analgesic and antipyretic medication. It is an amide and a derivative of acetaminophen, a widely used over-the-counter pain reliever and fever reducer. The chemical is structurally similar to acetaminophen, with the addition of a functional group that contains a nitrogen atom bonded to a carbonyl group, which gives it its amide classification. N-(2,4,6-Trimethylphenyl)acetamide works by inhibiting the production of prostaglandins, which are associated with pain and fever, in the brain and spinal cord. Its analgesic and antipyretic properties make it a popular choice for treating mild to moderate pain, such as headaches, muscle aches, and toothaches, as well as reducing fever. However, it is important to use this chemical with caution, as high doses or prolonged use can lead to liver damage.

InChI:InChI=1/C11H15NO/c1-7-5-8(2)11(9(3)6-7)12-10(4)13/h5-6H,1-4H3,(H,12,13)

Upstream product

• 60-35-5 acetamide 
• 88-05-1 2,4,6-trimethylaniline 
• 527-60-6 Mesitol 
• 125261-32-7 2,4,6-trimethylphenyl trifluoromethanesulfonate 
• 75-05-8 acetonitrile 
• 106-49-0 p-toluidine 
• 2050-43-3 N-(2,4-dimethylphenyl)acetamide 
• 112359-25-8 5-(trifluoromethyl)dibenzothiophenium trifluoromethanesulfonate 
• 103-89-9 4-Methylacetanilide 
• 64-19-7 acetic acid 
• 98-04-4 phenyltrimethylammonium iodide 
• 46005-00-9 Ethylidyne-(2,4,6-trimethyl-phenyl)-ammonium 
• 7647-01-0 hydrogenchloride 
• 586-76-5 4-Bromobenzoic acid 

Downstream Products

• 1431944-75-0 N-(2,4,6-trimethylphenyl)acetimidoyl chloride 
• 1598437-68-3 N-acetyl-N-mesitylbenzamide 
• 1148021-53-7 1-N-(4'-cyanophenyl)-2,4-dinitro-N-acetoxy-5-N-[(2',4',6'-trimethylphenyl)]benzene-1,5-diamine 
• 1139719-77-9 (E)-methyl 3-(3-acetylamino-2,4,6-trimethylphenyl)-3-(4-methylphenyl)acrylate 
• 1139719-80-4 N-{2,4,6-trimethyl-3-[(Z)-1-(4-methylphenyl)-3-oxobut-1-enyl]phenyl}acetamide 
• 1139719-79-1 (Z)-methyl 3-(3-acetylamino-2,4,6-trimethylphenyl)-3-(4-methoxyphenyl)acrylate 
• 49838-52-0 2,4,6-tris(methoxycarbonyl)nitrosobenzene 
• 15366-35-5 2-amino-1,3,5-benzenetricarboxylic acid trimethyl ester 
• 489-96-3 2-amino-1,3,5-benzenetricarboxylic acid 
• 13171-56-7 2,4,6-trimethyl-3,5-dinitroaniline 
• 1521-60-4 2,4,6-trimethyl-3-nitro-aniline 
• 79825-75-5 N-methyl-2,4,6-trimethyldiphenylamine 
• 23592-67-8 N-mesitylaniline 
• 40752-00-9 N-mesityl-N-methylacetamide 

Relevant articles and documents

On the Beckmann Rearrangement of Ketoximes: A Kinetic Study in Trifluoromethanesulfonic Acid

The formation and the destruction of an intermediate involved in the Beckmann rearrangement of 2,4,6-trimethylacetophenone oxime have been studied in concentrated trifluoromethanesulfonic acid by kinetic and spectroscopic measurements. Observed (kobs

New half-sandwich (η6-p-cymene)ruthenium(II) complexes with benzothiazole hydrazone Schiff base ligand: Synthesis, structural characterization and catalysis in transamidation of carboxamide with primary amines

Few half-sandwich (η6-p-cymene) ruthenium(II) complexes supported by benzothiazole hydrazone Schiff bases were synthesized. The new complexes possess the general formulae [Ru(η6-p-cymene)(L)Cl] (1-3) (L = salicyl((2-(benzothiazol-2-yl)hydrazono)methylphenol) (SAL-HBT), 2-((2-(benzothiazol-2-yl)hydrazono)methyl)-6 methoxyphenol) (VAN-HBT) or naphtyl-2-((2-(benzothiazol-2-yl)hydrazono)methyl phenol) (NAP-HBT). All compounds were fully studied by analytical, spectroscopic techniques (IR, NMR) and also by mass spectrometry. The solid state structure of the complex 3 reveals the coordination of p-cymene moieties with ruthenium(II) in a three-legged piano-stool geometry along with benzothiazole hydrazone Schiff base ligand in a monobasic bidentate fashion. The catalytic properties of the complexes were screened in transamidation of primary amide with amines after optimization with respect to solvent, substituents, time and catalyst loading. The results show that the complex 3 is the most efficient catalyst for the transamidation of carboxamides with amines.

Transition-Metal-Free C-C, C-O, and C-N Cross-Couplings Enabled by Light

Transition-metal-catalyzed cross-couplings to construct C-C, C-O, and C-N bonds have revolutionized chemical science. Despite great achievements, these metal catalysts also raise certain issues including their high cost, requirement of specialized ligands, sensitivity to air and moisture, and so-called "transition-metal-residue issue". Complementary strategy, which does not rely on the well-established oxidative addition, transmetalation, and reductive elimination mechanistic paradigm, would potentially eliminate all of these metal-related issues. Herein, we show that aryl triflates can be coupled with potassium aryl trifluoroborates, aliphatic alcohols, and nitriles without the assistance of metal catalysts empowered by photoenergy. Control experiments reveal that among all common aryl electrophiles only aryl triflates are competent in these couplings whereas aryl iodides and bromides cannot serve as the coupling partners. DFT calculation reveals that once converted to the aryl radical cation, aryl triflate would be more favorable to ipso substitution. Fluorescence spectroscopy and cyclic voltammetry investigations suggest that the interaction between excited acetone and aryl triflate is essential to these couplings. The results in this report are anticipated to provide new opportunities to perform cross-couplings.