152121-61-4Relevant academic research and scientific papers
A direct, one step synthesis of imidazoles from imines and acid chlorides: A palladium catalyzed multicomponent coupling approach
Siamaki, Ali R.,Arndtsen, Bruce A.
, p. 6050 - 6051 (2006)
A palladium-catalyzed one-step synthesis of imidazoles from imines and acid chlorides is described. A plausible mechanism for this multicomponent reaction is provided, which explains the selective incorporation of two different imines into the final product with perfect regiocontrol. Overall, this catalytic process provides a modular method to prepare imidazoles directly from building blocks that are all either commercially available or readily generated. Copyright
