152170-22-4

Upstream product

• 58040-74-7 octanoyl cyanide 
• 152170-19-9 <(2S,3S)-3-(benzyloxy)-1-phenylhex-5-yn-2-yl>amine 
• 152170-20-2 (2S,3S)-2--1-phenylhex-5-yn-3-ol 
• 152170-21-3 (2S,3S)-3-(benzyloxy)-2--1-phenylhex-5-yne 
• 111-64-8 n-octanoic acid chloride 
• 100-39-0 benzyl bromide 
• 120238-42-8 methyl (S)-2-(diphenylmethylideneamino)-3-phenylpropanoate 

Downstream Products

• 152170-23-5 (2S,3S,5R)-4-(benzyloxy)-2-(2'-cyano-1'-nonen-1'-yl)-1-methyl-5-(phenylmethyl)pyrrolidine 
• 125356-66-3 (+)-preussin 

Relevant academic research and scientific papers

Synthetic applications of imidotitanium-alkyne [2 + 2] cycloadditions. A concise, stereocontrolled total synthesis of the antifungal agent (+)-preussin

An efficient stereoselective total synthesis of (+)-preussin, (2S,3S,5R)-1-methyl-5-nonyl-2-(phenylmethyl)-3-pyrrolidinol (1), was achieved by way of a convergent, intramolecular imidotitanium-alkyne [2 + 2] cycloaddition-acyl cyanide condensation sequence.