152192-50-2

Upstream product

• 36140-19-9 dicyclohexylboron chloride 
• 116546-78-2 (S)-1-benzyloxy-2-methylpentan-3-one 
• 81927-55-1 O-benzyl 2,2,2-trichloroacetimidate 
• 74924-27-9 methyl (S)-3-benzyloxy-2-methylpropanoate 
• 116652-76-7 Weinreb amide of (S)-3-benzyloxy-2-methylpropionic acid 

Downstream Products

• 217944-58-6 (2S,4S,5S,6R)-1,7-Bis-benzyloxy-5-hydroxy-2,4,6-trimethyl-heptan-3-one 
• 261968-09-6 (2S,3R,4S,5S)-1-benzyloxy-2,4-dimethylhexane-3,5-diol 
• 261968-11-0 (2S,3R,4S,5S)-1-benzyloxy-3-(t-butyldimethylsilyloxy)-2,4-dimethylhexan-5-ol 
• 261968-10-9 (2S,3R,4S,5S)-1-benzyloxy-3,5-bis-(t-butyldimethylsilyloxy)-2,4-dimethylhexane 
• 303964-24-1 C₂₇H₅₁BO₄Si 
• 217944-59-7 (4S,5R,6S)-4-((S)-2-Benzyloxy-1-methyl-ethyl)-6-((R)-2-benzyloxy-1-methyl-ethyl)-2,2-di-tert-butyl-5-methyl-[1,3,2]dioxasilinane 
• 1040727-23-8 (2S,4S,5S,6R)-1-(benzyloxy)-6-((1S,3S,4R,5S)-1,4-dimethyl-2,8-dioxabicyclo[3.2.1]octan-3-yl)-5-hydroxy-2,4-dimethylheptan-3-one 
• 1109114-93-3 C₃₆H₅₈O₆Si 

Relevant academic research and scientific papers

Toward the total synthesis of the brasilinolides: Construction of a differentially protected C20-C38 segment

(Chemical Equation Presented) An efficient, convergent synthesis of a differentially protected C20-C38 segment of the brasilinolides is described. Iterative 1,4-syn aldol additions and ketone reductions were employed to construct the two related stereotet

Total synthesis of (-)-saliniketals A and B?

(Chemical Equation Presented) A stereocontrolled total synthesis of the orthinine decarboxylase inhibitors saliniketals A and B is described. Key features of the 17-step route include the use of two boron aldol/reduction sequences to control six of the ni

A practical synthesis of (+)-discodermolide and analogues: Fragment union by complex aldol reactions

A practical stereocontrolled synthesis of (+)-discodermolide (1) has been completed in 10.3% overall yield (23 steps longest linear sequence). The absolute stereochemistry of the C1-C6 (7), C9-C16 (8), and Csub

Total synthesis of the antimicrotubule agent (+)-discodermolide using boron-mediated aldol reactions of chiral ketones

With a similar mechanism of action to taxol, the title compound 1 is a particularly promising candidate for development in cancer chemotherapy. This efficient synthesis, based on stereocontrolled aldol reactions, should help to overcome the scarce natural

Stereoselective synthesis of an isomer of membrenone-C via an aldol based two directional chain extension

An isomer of Membrenone-C was prepared in 8 steps (17% yield) with 93% overall ds starting from the ethyl ketone (S)-10. Key steps are the boron- mediated aldol followed by anti selective reduction, giving the C6-C10 stereochemistry,