261968-09-6Relevant articles and documents
Total synthesis of 5-epi-Torrubiellutin C and its biological evaluation
Mahipal, Bodugam,Singh, Ashita,Ummanni, Ramesh,Chandrasekhar, Srivari
, p. 15917 - 15927 (2013/09/12)
The total synthesis of 5-epi-Torrubiellutin C is described in a fully stereocontrolled manner and linear sequence involving high yielding steps. The synthetic strategy involves the dicyclohexylboron chloride mediated Paterson's aldol protocol, Horner-Emmo
A practical synthesis of (+)-discodermolide and analogues: Fragment union by complex aldol reactions
Paterson,Florence,Gerlach,Scott,Sereinig
, p. 9535 - 9544 (2007/10/03)
A practical stereocontrolled synthesis of (+)-discodermolide (1) has been completed in 10.3% overall yield (23 steps longest linear sequence). The absolute stereochemistry of the C1-C6 (7), C9-C16 (8), and Csub
Total synthesis of the antimicrotubule agent (+)-discodermolide using boron-mediated aldol reactions of chiral ketones
Paterson, Ian,Florence, Gordon J.,Gerlach, Kai,Scott, Jeremy P.
, p. 377 - 380 (2007/10/03)
With a similar mechanism of action to taxol, the title compound 1 is a particularly promising candidate for development in cancer chemotherapy. This efficient synthesis, based on stereocontrolled aldol reactions, should help to overcome the scarce natural