152192-52-4

Upstream product

• 152192-51-3 (4S,5R,6R)-4-((S)-2-Benzyloxy-1-methyl-ethyl)-2,2-di-tert-butyl-6-isopropenyl-5-methyl-[1,3,2]dioxasilinane 
• 860295-66-5 2,2-Dimethyl-propionic acid (S)-2-[(4S,5R,6S)-6-((S)-2-benzyloxy-1-methyl-ethyl)-2,2-di-tert-butyl-5-methyl-[1,3,2]dioxasilinan-4-yl]-propyl ester 
• 860478-32-6 2,2-Dimethyl-propionic acid (2S,3S,4R,5S,6S)-7-benzyloxy-3,5-dihydroxy-2,4,6-trimethyl-heptyl ester 
• 618096-11-0 2,2-Dimethyl-propionic acid (2S,3S,4S,5S,6S)-7-benzyloxy-3-hydroxy-2,4,6-trimethyl-5-triethylsilanyloxy-heptyl ester 
• 116546-78-2 (S)-1-benzyloxy-2-methylpentan-3-one 
• 140925-38-8 (2S,4S,5R)-1-benzyloxy-5-hydroxy-2,4,6-trimethylhept-6-en-3-one 
• 140925-57-1 (3R,4R,5S,6S)-7-Benzyloxy-2,4,6-trimethyl-hept-1-ene-3,5-diol 

Downstream Products

• 152192-49-9 (R)-2-[(4R,5R,6S)-6-((S)-2-Benzyloxy-1-methyl-ethyl)-2,2-di-tert-butyl-5-methyl-[1,3,2]dioxasilinan-4-yl]-propionaldehyde 
• 140925-47-9 (2S,3S,4S,5S,6S)-7-Benzyloxy-2,4,6-trimethyl-heptane-1,3,5-triol 
• 152192-55-7 (E)-(2S,6R,7R,8R)-2-[(4S,5S,6S)-6-((S)-2-Benzyloxy-1-methyl-ethyl)-2,2-di-tert-butyl-5-methyl-[1,3,2]dioxasilinan-4-yl]-7-methoxy-6,8-dimethyl-10-triisopropylsilanyloxy-dec-3-en-5-one 
• 860295-58-5 (4S,5S,6S)-4-((S)-2-Benzyloxy-1-methyl-ethyl)-2,2-di-tert-butyl-6-[(S)-3-((2R,4R,6S)-4-methoxy-6-methyl-tetrahydro-pyran-2-yl)-1-methyl-prop-2-ynyl]-5-methyl-[1,3,2]dioxasilinane 
• 860295-67-6 (4S,5S,6S)-4-((S)-2-Benzyloxy-1-methyl-ethyl)-2,2-di-tert-butyl-6-((S)-3,3-dibromo-1-methyl-allyl)-5-methyl-[1,3,2]dioxasilinane 
• 860295-53-0 (4S,5S,6S)-4-((S)-2-Benzyloxy-1-methyl-ethyl)-2,2-di-tert-butyl-5-methyl-6-((S)-1-methyl-prop-2-ynyl)-[1,3,2]dioxasilinane 

Relevant academic research and scientific papers

Stereoselective synthesis of premisakinolide A, the monomeric counterpart of the marine 40-membered dimeric macrolide misakinolide A

(Chemical Equation Presented) The first synthesis of premisakinolide A, the monomeric counterpart of misakinolide A, the marine 40-membered macrolide displaying potent activity against a variety of human carcinoma cell lines, has been reported. The strate

The total synthesis of scytophycin C. Part 1: Stereocontrolled synthesis of the C1-C32 protected seco acid

A stereocontrolled synthesis of the C1-C32 seco acid derivative 9 for scytophycin C (1) was completed in 14 steps (18.2% yield, 85% ds) from aldehyde (S)-18. Key steps include: (i) the asymmetric crotylboration of (S)- 18 to give hom

Studies in marine macrolide synthesis: A stereocontrolled synthesis of a C17- C32 subunit of scytophycin C

The C17-C32 subunit 8 of scytophycin C was prepared in 11 steps (19% yield, 83% ds) from (S)-12. Key features include the dipropionate aldol construction of the stereopentad 11, the Brown asymmetric crotylboration leading to 10, followed by their Ba(OH)2-induced, Horner-Emmons coupling to give 23, and the BF3·OEt2-promoted allylation, 25 → 26.