152302-59-5Relevant academic research and scientific papers
An efficient synthesis of enantiopure SDZ 267-489 via a resolution/racemization method
Xu, Daqiang,Mattner, Paul G.,Kucerovy, Andrew,Prasad, Kapa,Repic, Oljan
, p. 747 - 754 (1996)
A new synthesis of (R)-3-methyl-5-phenyl-5H-thiazolo[2,3-b]quinazoline 1, a serum HDL cholesterol raising agent, is described utilizing a resolution of the racemic compound with D-tartaric acid. The undesired S-enantiomer was recycled using either a photochemical or thermal electrocyclic ring opening/closing reaction making the synthesis economical.
Antiatherosclerotic substituted phenylquinazoline derivatives
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, (2008/06/13)
The invention relates to substituted phenylquinazoline derivatives. It concerns the compounds of formula I wherein the substituents have various significances. They may be obtained by a process comprising dehydration, ring closure and/or alkylation, and optional recovery in racemic or optically active, in free base or acid addition salt form. They possess pharmacological activity, in particular,they raise the blood serum high density lipoprotein level and are thus indicated for use in the treatment of atherosclerosis.
