Tetrahedron Asymmetry p. 747 - 754 (1996)
Update date:2022-07-29
Topics:
Xu, Daqiang
Mattner, Paul G.
Kucerovy, Andrew
Prasad, Kapa
Repic, Oljan
A new synthesis of (R)-3-methyl-5-phenyl-5H-thiazolo[2,3-b]quinazoline 1, a serum HDL cholesterol raising agent, is described utilizing a resolution of the racemic compound with D-tartaric acid. The undesired S-enantiomer was recycled using either a photochemical or thermal electrocyclic ring opening/closing reaction making the synthesis economical.
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Doi:10.1021/om00035a013
(1993)Doi:10.1021/jo01266a016
(1968)Doi:10.1016/j.tetlet.2013.11.033
(2014)Doi:10.1021/ol4035897
(2014)Doi:10.1021/ja00076a024
(1993)Doi:10.1021/jo500877m
(2014)
