152338-04-0Relevant articles and documents
New efficient method for the synthesis of the antiviral agent carbovir
Jung, Michael E.,Rhee, Hakjune
, p. 4449 - 4452 (1993)
An efficient synthesis of (±)-carbovir 1 and simple des(hydroxymethyl) analogues, e.g., 5, is reported which uses a new approach for attaching nucleoside bases to cycloalkene systems.
Synthesis of 4-substituted-1,2,3-triazole carbanucleoside analogues of ribavirin via click chemistry
Perez-Castro, Isabel,Caamano, Olga,Fernandez, Franco,Garcia, Marcos D.,Lopez, Carmen,De Clercq, Erik
, p. 3805 - 3813 (2008/10/09)
The synthesis and biological evaluation as antiviral agents of a series of racemic 4-aryl-1,2,3-triazolo-2′,3′-dideoxy-2′- iodocarbanucleosides and 4-aryl-1,2,3-triazolo-2′,3′-dideoxy- 2′,3′-didehydrocarbanucleosides is presented. These compounds were produced using a click chemistry approach, with the iodoazide 13a as the key intermediary. The Royal Society of Chemistry 2007.
