118237-87-9Relevant articles and documents
A new nucleophilic ring opening of an activated cyclopropane and a formal synthesis of (+/-)-carbovir.
Tanimori,Tsubota,He,Nakayama
, p. 2091 - 2093 (2007/10/02)
The reaction of bicyclo[3.1.0]hexane 1, possessing a doubly activated cyclopropane ring, with acetic acid and potassium acetate in DMSO proceeded smoothly to give the adduct 2 in good yield. A formal total synthesis of the potent anti-HIV agent (+/-)-carb
New efficient method for the synthesis of the antiviral agent carbovir
Jung, Michael E.,Rhee, Hakjune
, p. 4449 - 4452 (2007/10/02)
An efficient synthesis of (±)-carbovir 1 and simple des(hydroxymethyl) analogues, e.g., 5, is reported which uses a new approach for attaching nucleoside bases to cycloalkene systems.
Synthesis and anti-HIV activity of carbocyclic 2',3'-didehydro-2',3'-dideoxy 2,6-disubstituted purine nucleosides
Vince,Hua
, p. 17 - 21 (2007/10/02)
(±)-cis-[4-[(2,5-Diamino-6-chloropyrimidinyl)amino]-2-cyclopentenyl]c arbinol (5a) was synthesized from 2-amino-4,6-dichloropyrimidine and cis-4-(hydroxymethyl)cyclopenteylamine (2a) by subsequent preparation of the 5-[(4-chlorophenyl)azo] derivative of t