118237-87-9

Usage

Uses

Used in Pharmaceutical Industry:
(-)-(1S,4R)-4-(2'-amino-6'-chloro-9'H-purin-9'-yl)cyclopent-2-enylmethanol is used as a potential pharmaceutical agent for its antiviral and anticancer properties. The presence of the purine derivative, which is known for its biological activities, suggests that (-)-(1S,4R)-4-(2'-amino-6'-chloro-9'H-purin-9'-yl)cyclopent-2-enylmethanol could be developed into a drug to combat viral infections and cancer cells.
Used in Drug Development Research:
In the field of drug development, (-)-(1S,4R)-4-(2'-amino-6'-chloro-9'H-purin-9'-yl)cyclopent-2-enylmethanol serves as a subject for further research. Its unique stereochemistry and functional groups may provide insights into the design of new drugs with improved efficacy and selectivity, contributing to the advancement of medicinal chemistry.

Upstream product

• 122624-77-5 (+/-)-cis-<4-<(2,5-diamino-6-chloro-4-pyrimidinyl)amino>-2-cyclopentenyl>carbinol 
• 122-51-0 orthoformic acid triethyl ester 
• 76909-89-2 cis-(+/-)-3-acetoxy-5-(acetoxymethyl)cyclopentene 
• 10310-21-1 2-Amino-6-chloropurin 
• 25125-21-7 4-(hydroxymethyl)cyclopentene 
• 7129-41-1 6-oxabicyclo[3.1.0]hex-2-ene 
• 229177-39-3 1-amino-4-(hydroxymethyl)-2-cyclopentene 
• 122624-75-3 (+/-)-cis-<4-<<2-amino-6-chloro-5-<(4-chlorophenyl)azo>-4-pyrimidinyl>amino>-2-cyclopentenyl>carbinol 
• 64646-09-9 (+/-)-3-(hydroxymethyl)cyclopentanone 
• 134628-04-9 cis-(+/-)-2-Amino-6-chloro-9-<4-(nitromethyl)-2-cyclopenten-1-yl>-9H-purine 
• 122624-73-1 (+/-)-cis-<4-<(2-amino-6-chloro-4-pyrimidinyl)amino>-2-cyclopentenyl>carbinol 
• 61865-50-7 Acetic acid 4-acetylamino-cyclopent-2-enylmethyl ester 
• 134628-01-6 2-amino-6-chloro-9<(1'β,4'β)-4'-hydroxycyclopent-2'-enyl>purine 
• 134628-03-8 <1α,4α>-(+/-)-2-Amino-6-chloro-9-<4--2-cyclopenten-1-yl>-9H-purine 

Downstream Products

• 118353-05-2 (+/-)-cis-2-amino-1,9-dihydro-9-[4-(hydroxymethyl)-2-cyclopenten-1-yl]-6H-purin-6-one 
• 118237-88-0 (+/-)-cis-<4-(2,6-diamino-9H-purin-9-yl)-2-cyclopentenyl>carbinol 
• 118353-05-2 cis-<4-(hydroxymethyl)-2-cyclopentenyl>guanine 

Relevant academic research and scientific papers

A new nucleophilic ring opening of an activated cyclopropane and a formal synthesis of (+/-)-carbovir.

The reaction of bicyclo[3.1.0]hexane 1, possessing a doubly activated cyclopropane ring, with acetic acid and potassium acetate in DMSO proceeded smoothly to give the adduct 2 in good yield. A formal total synthesis of the potent anti-HIV agent (+/-)-carb

Concise Racemic and Highly Enantioselective Approaches to Key Intermediates for the Syntheses of Carbocyclic Nucleosides and pseudo-Ribofuranoses: Formal Syntheses of Carbovir

A regio- and stereo-specific synthesis of cis-(+/-)-3-acetoxy-5-(acetoxymethyl)cyclopentene 3 from cyclopent-3-enecarboxylic acid 4 via a bromolactonisation strategy is described.Pd-catalysed coupling of the cis-(+/-)-diacetate 3 with 2-amino-6-chloropurine or 2,6-diaminopurine leads to the formal syntheses of carbovir 1.A synthesis of the (1R)-cis-diacetate 15 (R = Ac) is described via a highly enantioselective rearrangement of cis-6-oxabicyclohexane-3-methanol 13 (also prepared from the acid 4) using the dilithium salt of (1S,2R)-norephedrine.

New efficient method for the synthesis of the antiviral agent carbovir

An efficient synthesis of (±)-carbovir 1 and simple des(hydroxymethyl) analogues, e.g., 5, is reported which uses a new approach for attaching nucleoside bases to cycloalkene systems.

Synthesis and anti-HIV activity of carbocyclic 2',3'-didehydro-2',3'-dideoxy 2,6-disubstituted purine nucleosides

(±)-cis-[4-[(2,5-Diamino-6-chloropyrimidinyl)amino]-2-cyclopentenyl]c arbinol (5a) was synthesized from 2-amino-4,6-dichloropyrimidine and cis-4-(hydroxymethyl)cyclopenteylamine (2a) by subsequent preparation of the 5-[(4-chlorophenyl)azo] derivative of t