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152565-98-5

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152565-98-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 152565-98-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,2,5,6 and 5 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 152565-98:
(8*1)+(7*5)+(6*2)+(5*5)+(4*6)+(3*5)+(2*9)+(1*8)=145
145 % 10 = 5
So 152565-98-5 is a valid CAS Registry Number.
InChI:InChI=1/C20H20FNO/c21-19-8-6-16(7-9-19)17-10-13-22(14-11-17)15-12-20(23)18-4-2-1-3-5-18/h1-10H,11-15H2

152565-98-5Downstream Products

152565-98-5Relevant articles and documents

Structure-activity relationship of new antimalarial 1-aryl-3-susbtituted propanol derivatives: Synthesis, preliminary toxicity profiling, parasite life cycle stage studies, target exploration, and targeted delivery

Quiliano, Miguel,Pabón, Adriana,Moles, Ernest,Bonilla-Ramirez, Leonardo,Fabing, Isabelle,Fong, Kim Y.,Nieto-Aco, Diego A.,Wright, David W.,Pizarro, Juan C.,Vettorazzi, Ariane,López de Cerain, Adela,Deharo, Eric,Fernández-Busquets, Xavier,Garavito, Giovanny,Aldana, Ignacio,Galiano, Silvia

, p. 489 - 514 (2018)

Design, synthesis, structure-activity relationship, cytotoxicity studies, in silico drug-likeness, genotoxicity screening, and in vivo studies of new 1-aryl-3-substituted propanol derivatives led to the identification of nine compounds with promising in vitro (55, 56, 61, 64, 66, and 70–73) and in vivo (66 and 72) antimalarial profiles against Plasmodium falciparum and Plasmodium berghei. Compounds 55, 56, 61, 64, 66 and 70–73 exhibited potent antiplasmodial activity against chloroquine-resistant strain FCR-3 (IC50s 50s 0.7 μM for 3D7, D6, FCR-3 and C235). All of these compounds share appropriate drug-likeness profiles and adequate selectivity indexes (77 SI 184) as well as lack genotoxicity. In vivo efficacy tests in a mouse model showed compounds 66 and 72 to be promising candidates as they exhibited significant parasitemia reductions of 96.4% and 80.4%, respectively. Additional studies such as liver stage and sporogony inhibition, target exploration of heat shock protein 90 of P. falciparum, targeted delivery by immunoliposomes, and enantiomer characterization were performed and strongly reinforce the hypothesis of 1-aryl-3-substituted propanol derivatives as promising antimalarial compounds.

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