15258-05-6

Basic information

• Product Name: 3,5-dichloro-N-(2-chloroethyl)benzamide
• CAS NO: 15258-05-6
• Molecular Formula: C₉H₈Cl₃NO
• Molecular Weight: 252.5249
• Mol File: 15258-05-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 348°C at 760 mmHg
• Flash Point: 164.3°C
• Density: 1.39g/cm³
• Vapor Pressure: 5.18E-05mmHg at 25°C
• Refractive Index: 1.565
• CAS DataBase Reference: 3,5-dichloro-N-(2-chloroethyl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-dichloro-N-(2-chloroethyl)benzamide(15258-05-6)
• EPA Substance Registry System: 3,5-dichloro-N-(2-chloroethyl)benzamide(15258-05-6)

Safety Data

• Hazardous Substances Data: 15258-05-6(Hazardous Substances Data)

Upstream product

• 2905-62-6 3,5-dichlorobenzoyl chloride 
• 689-98-5 chloroethylamine 
• 344307-65-9 3,5-dichloro-N-(2-hydroxyethyl)benzamide 
• 870-24-6 2-chloroethanamine hydrochloride 
• 51-36-5 3,5-dichlorobenzoic acid 

Downstream Products

• 82891-88-1 2-(3,5-dichlorophenyl)-4,5-dihydrooxazole 

Relevant articles and documents

Deuterium-substituted 3-(methylsulfonyl)-L-phenylalanine derivative and medicine composition, medicine preparation and application thereof

The invention provides a deuterium-substituted 3-(methylsulfonyl)-L-phenylalanine derivative and a medicine composition, a medicine preparation and application thereof. The deuterium-substituted 3-(methylsulfonyl)-L-phenylalanine derivative has a structure shown in a formula I. A compound provided by the invention and the derivative thereof have good LFA-1 antagonistic activity, excellent pharmacodynamics property and lower toxicity. The formula I is shown in the description, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, R18, R19, R20 and R21 are respectively and independently hydrogen or deuterium, and at least contain one deuterium; R is hydrogen.

Design and synthesis of 4-benzylpiperidine carboxamides as dual serotonin and norepinephrine reuptake inhibitors

A series of 4-benzylpiperidine carboxamides were designed and synthesized, and tested for their dual (serotonin and norepinephrine) reuptake inhibition. The synthesis of 4-benzylpiperidine carboxamides involved two main steps: amidation and substitution. Derivatives with 3 carbon linker displayed better activity than with 2 carbon linker. 4-Biphenyl- and 2-naphthyl-substituted derivatives 7e and 7j showed greater dual reuptake inhibition than standard drug venlafaxine HCl.