15258-05-6Relevant academic research and scientific papers
Novel carboxamide derivates salt and use of the same
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, (2018/02/10)
The present invention relates to a novel carboxamide derivative salt having mental disorder remedial effects, and uses thereof. The salt as a compound represented by chemical formula 1 or a pharmaceutically allowable salt thereof can treat or prevent mental disorders such as depression, anxiety disorders, panic disorders, obsessive-compulsive disorders, phobias, attention deficit hyperactivity disorder, etc., can increase a remission rate, has fewer side effects and can effectively inhibit reabsorption of serotonin, norepinephrine or dopamine.COPYRIGHT KIPO 2017
Deuterium-substituted 3-(methylsulfonyl)-L-phenylalanine derivative and medicine composition, medicine preparation and application thereof
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Paragraph 0034; 0079; 0080, (2017/08/31)
The invention provides a deuterium-substituted 3-(methylsulfonyl)-L-phenylalanine derivative and a medicine composition, a medicine preparation and application thereof. The deuterium-substituted 3-(methylsulfonyl)-L-phenylalanine derivative has a structure shown in a formula I. A compound provided by the invention and the derivative thereof have good LFA-1 antagonistic activity, excellent pharmacodynamics property and lower toxicity. The formula I is shown in the description, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, R18, R19, R20 and R21 are respectively and independently hydrogen or deuterium, and at least contain one deuterium; R is hydrogen.
Design and synthesis of 4-benzylpiperidine carboxamides as dual serotonin and norepinephrine reuptake inhibitors
Paudel, Suresh,Cao, Yongkai,Guo, Shuohan,An, Byeongkwan,Kim, Kyeong-Man,Cheon, Seung Hoon
, p. 6418 - 6426 (2015/10/05)
A series of 4-benzylpiperidine carboxamides were designed and synthesized, and tested for their dual (serotonin and norepinephrine) reuptake inhibition. The synthesis of 4-benzylpiperidine carboxamides involved two main steps: amidation and substitution. Derivatives with 3 carbon linker displayed better activity than with 2 carbon linker. 4-Biphenyl- and 2-naphthyl-substituted derivatives 7e and 7j showed greater dual reuptake inhibition than standard drug venlafaxine HCl.
Oxazolines. 3. Regioselective Synthesis of 2-(Monosubstituted phenyl) and/or Unsymmetrically 2-(Disubstituted phenyl) 2-Oxazolines by Cross-Coupling Grignard Reagents to (Haloaryl)-2-oxazolines
Pridgen, Lendon N.
, p. 4319 - 4323 (2007/10/02)
2-(Monosubstituted phenyl) 2-oxazoline 5 (R = H) and unsymmetrically 2-(disubstituted phenyl) 2-oxazolines 5 have been prepared by cross-coupling alkyl and aryl Grignard reagents to 2-(mono- and dihalogenated phenyl) 2-oxazolines 2 and 3 (X = halogen), re
