344307-65-9Relevant academic research and scientific papers
Scalable Process for Making 5,7-Dichlorotetrahydroisoquinoline-6-carboxylic Acid Using Methylene as the Protecting Group
Xu, Wanbin,Gong, Xudong,Odilov, Abdullajon,Hu, Tianwen,Jiang, Xiangrui,Zhu, Fuqiang,Guo, Shuang,Jiang, Dehui,Wu, Mingjun,Shen, Jingshan
, p. 2447 - 2452 (2021/11/13)
The development of an industrially scalable synthetic route for 5,7-dichlorotetrahydroisoquinoline-6-carboxylic acid (1), a key starting material for lifitegrast, is described. This route includes the following features: (1) tetrahydroisoquinoline19was pr
Oxazolines. 3. Regioselective Synthesis of 2-(Monosubstituted phenyl) and/or Unsymmetrically 2-(Disubstituted phenyl) 2-Oxazolines by Cross-Coupling Grignard Reagents to (Haloaryl)-2-oxazolines
Pridgen, Lendon N.
, p. 4319 - 4323 (2007/10/02)
2-(Monosubstituted phenyl) 2-oxazoline 5 (R = H) and unsymmetrically 2-(disubstituted phenyl) 2-oxazolines 5 have been prepared by cross-coupling alkyl and aryl Grignard reagents to 2-(mono- and dihalogenated phenyl) 2-oxazolines 2 and 3 (X = halogen), re
