15258-44-3Relevant articles and documents
B(C6F5)3-Catalyzed Deoxygenative Reduction of Amides to Amines with Ammonia Borane
Pan, Yixiao,Luo, Zhenli,Han, Jiahong,Xu, Xin,Chen, Changjun,Zhao, Haoqiang,Xu, Lijin,Fan, Qinghua,Xiao, Jianliang
supporting information, p. 2301 - 2308 (2019/01/30)
The first B(C6F5)3-catalyzed deoxygenative reduction of amides into the corresponding amines with readily accessible and stable ammonia borane (AB) as a reducing agent under mild reaction conditions is reported. This metal-free protocol provides facile access to a wide range of structurally diverse amine products in good to excellent yields, and various functional groups including those that are reduction-sensitive were well tolerated. This new method is also applicable to chiral amide substrates without erosion of the enantiomeric purity. The role of BF3 ? OEt2 co-catalyst in this reaction is to activate the amide carbonyl group via the in situ formation of an amide-boron adduct. (Figure presented.).
A strategy of two-step tandem catalysis towards direct N-alkylation of nitroarenes with ethanol via facile fabricated novel Co-based catalysts derived from coordination polymers
Wang, Jing,Qi, Tianqinji,Li, Zhibin,She, Wei,Li, Xuewei,Li, Jingfang,Yan, Pengfei,Li, Weizuo,Li, Guangming
, p. 106 - 118 (2019/07/19)
Three novel N-doped carbon supported Co/Co3O4 catalysts, namely, Co@CN-hmta, Co@CN-larg and Co-Co3O4@CN-bipy, with sheet-, worm-, honeycomb-like morphologies respectively, have been fabricated by the pyrolysis of well-defined coordination polymers (CPs). Upon the as-prepared catalysts were applied for the reaction of N-alkylation of nitroarenes with ethanol, a direct two-step tandem reaction is realized, in which the Co@CN-hmta delivers 100% conversion/selectivity of N-ethylaniline/N,N-diethylaniline from the direct N-alkylation of nitroarenes with ethanol. The kinetic studies were conducted to confirm that the N-alkylation of aniline with ethanol is the rate-determining step in the two-step tandem reaction. The SEM/EDX, XRD, Raman, TEM, XPS, and CO2-TPD characterization results have revealed that sizes and dispersion of metallic Co, amount of structural defects and surface Lewis basicity towards three catalysts can be tuned by changing the structures of Co-based CPs designed by different organic linkers, which may also help to understand the preparation of industrial catalysts on a molecular level. The optimized Co@CN-hmta catalyst is easily recycled by using the external magnet for successive reuses without any loss in both activity and selectivity. To the best of our knowledge, this is the first carbon-nitrogen species supported Co/Co3O4 catalysts derived from the CPs, which could effectively catalyzed the N-alkylation of nitroarenes with ethanol to produce the secondary amines and/or tertiary amines. This low-cost, recyclable and easy scale-up N-doped carbon supported catalyst may be of potential application in various heterogeneous catalytic reactions.
A sound shielding through the level three-stage amine instead new method should be secondary amine
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Paragraph 0033; 0034; 0035, (2017/06/02)
The invention discloses a novel method for preparing secondary amine by a reaction of primary amine and tertiary amine. The method comprises the following steps of 1, adding primary amine and tertiary amine into a reaction container according to a mole ratio of primary amine to tertiary amine of 1: 3, adding [(Bt)2*Ir*P(nBu)3]OTf as a catalyst (wherein Bt represents phenylbenzothiazole) into the reaction container, adding an organic solvent into the reaction container, and carrying out a reaction process at a temperature of 120-160 DEG C for 6-12h, wherein a mole ratio of primary amine, tertiary amine to catalyst is 1: 3: 0.01, and 2, carrying out purification by a silica gel column of 200-300 meshes, pre-leaching the silica gel column by 20-50mL of petroleum ether, carrying out elution on the leacheate at a leacheate flowing rate of 1-2mL/min for 3-6h so that the solvent is removed and the corresponding secondary amine product is obtained. A research result shows that the novel method for producing secondary amine by a reaction of primary amine and tertiary amine has the characteristics of mild conditions, high conversion rate and no pollutant. The method solves the problems of the existing secondary amine synthesis method and improves secondary amine synthesis.
