15263-48-6

Basic information

• Product Name: (2-phenyl-4,5-dihydro-1,3-oxazol-4-yl)methanol
• Synonyms: (2-Phenyl-4,5-dihydro-1,3-oxazol-4-yl)methanol; 4-oxazolemethanol, 4,5-dihydro-2-phenyl-
• CAS NO: 15263-48-6
• Molecular Formula: C₁₀H₁₁NO₂
• Molecular Weight: 177.1998
• Mol File: 15263-48-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 330.3°C at 760 mmHg
• Flash Point: 153.6°C
• Density: 1.22g/cm³
• Vapor Pressure: 6.73E-05mmHg at 25°C
• Refractive Index: 1.588
• CAS DataBase Reference: (2-phenyl-4,5-dihydro-1,3-oxazol-4-yl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (2-phenyl-4,5-dihydro-1,3-oxazol-4-yl)methanol(15263-48-6)
• EPA Substance Registry System: (2-phenyl-4,5-dihydro-1,3-oxazol-4-yl)methanol(15263-48-6)

Safety Data

• Hazardous Substances Data: 15263-48-6(Hazardous Substances Data)

Usage

General Description

(2-phenyl-4,5-dihydro-1,3-oxazol-4-yl)methanol, also known as POM, is a chemical compound with the molecular formula C10H11NO2. It is a white solid that is sometimes used in organic synthesis as a reagent or building block. POM has also been studied for its potential pharmaceutical properties, particularly as an inhibitor of enzymes involved in cancer and other diseases. It is important to handle POM carefully, as it can be toxic if ingested or inhaled, and it may also be harmful to the environment if not properly disposed of.

Upstream product

• 98-88-4 benzoyl chloride 
• 100-47-0 benzonitrile 
• 534-03-2 serinol 
• 825-60-5 benzimidic acid ethyl ester 

Downstream Products

• 138832-93-6 2-phenyl-4-(p-toluenesulfonyloxymethyl)oxazoline 
• 104005-03-0 4-[[2-phenyl-(2-oxazolin-4-yl)]methylthio]phenol 
• 138833-00-8 (2-Phenyl-4,5-dihydro-oxazol-4-yl)-acetonitrile 
• 160149-06-4 (RS)-4-iodomethyl-2-phenyl-4,5-dihydrooxazole 
• 151069-69-1 RS-2-phenyl-4-vinyl-2-oxazoline 
• 160149-03-1 (RS)-4-bromomethyl-2-phenyl-4,5-dihydrooxazole 
• 151312-91-3 2-phenyl-4-<(11-phenylundecyloxy)methyl>-2-oxazoline 
• 151312-90-2 2-Phenyl-4-(16-phenyl-hexadecyloxymethyl)-4,5-dihydro-oxazole 
• 101007-72-1 4-Octadecyloxymethyl-2-phenyl-4,5-dihydro-oxazole 
• 151312-92-4 4-Hexadecyloxymethyl-2-phenyl-4,5-dihydro-oxazole 
• 23546-99-8 N-<1.3-Dichlor-2-propyl>-benzamid 

Relevant articles and documents

Aza-Oxyallyl Cation Driven 3-Amido Oxetane Rearrangement to 2-Oxazolines: Access to Oxazoline Amide Ethers

Herein, we report a highly facile and unprecedented activation of 3-amido oxetanes to synthesize 2-oxazoline amide ethers using a transient electrophilic aza-oxyallyl cation as an activating as well as an alkylating agent under mild reaction conditions. The aza-oxyallyl cation driven intramolecular rearrangement of 3-amido oxetanes to 2-oxazolines is the hallmark of this transformation and is a new addition to the reactivity profile of aza-oxyallyl cations.

Stereoselective Cycloaddition of Nitrile Oxides to 4-Vinyl-Oxazolines and -Oxazolidines

Cycloaddition of nitrile oxides to 4-vinyl-2-oxazoline 1 and to 4-vinyloxazolidine 2 afford diastereomeric mixtures of 2-isoxazolines in which the erythro product predominates (32-64percent d.e.).In contrast, the corresponding reactions with acyclic analogue 3 favoured the threo-adducts and were less selective (8-20percent d.e.).Key Words: 1,3-dipolar cycloaddition; nitrile oxides; isoxazolines