15263-48-6

Usage

Uses

Used in Pharmaceutical Industry:
(2-phenyl-4,5-dihydro-1,3-oxazol-4-yl)methanol is used as an enzyme inhibitor for its potential role in treating cancer and other diseases. Its ability to inhibit specific enzymes makes it a candidate for therapeutic intervention in conditions where enzyme activity is a contributing factor.
Used in Organic Synthesis:
In the field of organic synthesis, (2-phenyl-4,5-dihydro-1,3-oxazol-4-yl)methanol is used as a reagent or building block. Its unique structure allows it to be incorporated into more complex molecules, facilitating the development of new compounds with various applications.
Used in Research and Development:
(2-phenyl-4,5-dihydro-1,3-oxazol-4-yl)methanol is utilized in research and development settings to explore its properties and potential applications. This includes studying its interactions with biological systems and evaluating its efficacy and safety in preclinical and clinical studies.

Upstream product

• 100-47-0 benzonitrile 
• 534-03-2 serinol 
• 98-88-4 benzoyl chloride 
• 825-60-5 benzimidic acid ethyl ester 

Downstream Products

• 23546-99-8 N-<1.3-Dichlor-2-propyl>-benzamid 
• 138832-93-6 2-phenyl-4-(p-toluenesulfonyloxymethyl)oxazoline 
• 104005-03-0 4-[[2-phenyl-(2-oxazolin-4-yl)]methylthio]phenol 
• 138833-00-8 (2-Phenyl-4,5-dihydro-oxazol-4-yl)-acetonitrile 
• 160149-06-4 (RS)-4-iodomethyl-2-phenyl-4,5-dihydrooxazole 
• 151069-69-1 RS-2-phenyl-4-vinyl-2-oxazoline 
• 151312-91-3 2-phenyl-4-<(11-phenylundecyloxy)methyl>-2-oxazoline 
• 151312-90-2 2-Phenyl-4-(16-phenyl-hexadecyloxymethyl)-4,5-dihydro-oxazole 
• 101007-72-1 4-Octadecyloxymethyl-2-phenyl-4,5-dihydro-oxazole 
• 151312-92-4 4-Hexadecyloxymethyl-2-phenyl-4,5-dihydro-oxazole 
• 160149-03-1 (RS)-4-bromomethyl-2-phenyl-4,5-dihydrooxazole 

Relevant academic research and scientific papers

Aza-Oxyallyl Cation Driven 3-Amido Oxetane Rearrangement to 2-Oxazolines: Access to Oxazoline Amide Ethers

Herein, we report a highly facile and unprecedented activation of 3-amido oxetanes to synthesize 2-oxazoline amide ethers using a transient electrophilic aza-oxyallyl cation as an activating as well as an alkylating agent under mild reaction conditions. The aza-oxyallyl cation driven intramolecular rearrangement of 3-amido oxetanes to 2-oxazolines is the hallmark of this transformation and is a new addition to the reactivity profile of aza-oxyallyl cations.

Efficient synthesis and antibacterial evaluation of (±)-Yanglingmycin and its analogues

An efficient synthetic route was developed for the large-scale preparation of (±)-Yanglingmycin and its analogues. Three series of derivatives of (±)-Yanglingmycin were synthesized and the structures of all compounds were elucidated by analyses of NMR and ESI-MS spectra data. Moreover, their antibacterial activities against seven species of bacteria were systematically evaluated by the micro-broth dilution method, most of which displayed considerable activity. It was worth noting that compounds 5b, 5c, 5d, 6g, and 7 were found to be the most promising leading candidates, with peak MIC values of 0.98 μg.mL-1 for Bacillus subtilis, which is superior to positive controls (MIC = 3.91 μg.mL-1). The above results might lay the firm foundation for the design and synthesis of novel antibacterial drugs based on (±)-Yanglingmycin.

Stereoselective Cycloaddition of Nitrile Oxides to 4-Vinyl-Oxazolines and -Oxazolidines

Cycloaddition of nitrile oxides to 4-vinyl-2-oxazoline 1 and to 4-vinyloxazolidine 2 afford diastereomeric mixtures of 2-isoxazolines in which the erythro product predominates (32-64percent d.e.).In contrast, the corresponding reactions with acyclic analogue 3 favoured the threo-adducts and were less selective (8-20percent d.e.).Key Words: 1,3-dipolar cycloaddition; nitrile oxides; isoxazolines