152774-41-9Relevant academic research and scientific papers
Alkynyliodonium salt mediated alkynylation of azlactones: Fast access to Cα-tetrasubstituted α-amino acid derivatives
Finkbeiner, Peter,Weckenmann, Nicole M.,Nachtsheim, Boris J.
, p. 1326 - 1329 (2014/04/03)
An efficient electrophilic alkynylation of azlactones (oxazol-5(4H)-ones) is developed using alkynyl(phenyl)iodonium salts as the electrophilic alkyne source. After remarkably short reaction times, the desired alkyne functionalized azlactones are obtained in 60-97% yield and can be transformed easily into a variety of quaternary α-amino acid derivatives.
Synthesis of new bicyclic lactam peptidomimetics by ring-closing metathesis reactions
Colombo, Lino,Di Giacomo, Marcello,Vinci, Valerio,Colombo, Matteo,Manzoni, Leonardo,Scolastico, Carlo
, p. 4501 - 4513 (2007/10/03)
An efficient and versatile synthetic method for the preparation of new fused bicyclic lactams 3a and 3b is described. The spirane cyclopentane nucleus was easily installed by diallylation of the pyroglutamate derivative 18 followed by ring-closing metathe
Formal α-Vinylation of Amino Acids. Use of a New Benzeneselenolate Equivalent
Pedersen, Michelle L.,Berkowitz, David B.
, p. 6965 - 6975 (2007/10/02)
A new synthetic approach to the formal α-vinylation of α-amino acids is described, in which the readily available electrophile, ethylene oxide, serves as the vinyl cation equivalent.N-Benzoyl α-amino esters bearing appropriate side-chain protecting groups
