1528-39-8

Basic information

• Product Name: 3-phenylpentan-2-one
• CAS NO: 1528-39-8
• Molecular Formula: C₁₁H₁₄O
• Molecular Weight: 162.2283
• Mol File: 1528-39-8.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 227.4°C at 760 mmHg
• Flash Point: 87.4°C
• Density: 0.956g/cm³
• Vapor Pressure: 0.0779mmHg at 25°C
• Refractive Index: 1.498
• CAS DataBase Reference: 3-phenylpentan-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-phenylpentan-2-one(1528-39-8)
• EPA Substance Registry System: 3-phenylpentan-2-one(1528-39-8)

Safety Data

• Hazardous Substances Data: 1528-39-8(Hazardous Substances Data)

Upstream product

• 56051-24-2 1,2-epoxy-2-methyl-1-phenyl-butane 
• 917-64-6 methyl magnesium iodide 
• 60-29-7 diethyl ether 
• 855243-42-4 3-methyl-2-phenyl-butane-1,3-diol 
• 938-87-4 2-methyl-1-phenyl-butan-1-one 
• 917-54-4 methyllithium 
• 90-27-7 2-Phenylbutyric acid 
• 107-87-9 2-Pentanone 
• 74-96-4 ethyl bromide 
• 103-79-7 1-phenyl-acetone 
• 74-85-1 ethene 
• 368-39-8 triethyloxonium fluoroborate 
• 108-24-7 acetic anhydride 
• 934-11-2 (1-Chloro-propyl)-benzene 

Downstream Products

• 101866-13-1 4-phenyl-1-piperidino-hexan-3-one; hydrochloride 
• 101775-48-8 1-dimethylamino-4-phenyl-hexan-3-one 
• 15329-81-4 3-benzyl-3-phenylpentan-2-one 
• 73862-61-0 3-(4-Nitro-phenyl)-3-phenyl-pentan-2-one 
• 73862-66-5 3-(2-Nitro-phenyl)-3-phenyl-pentan-2-one 
• 73862-69-8 3-(2,4-Dinitro-phenyl)-3-phenyl-pentan-2-one 
• 73862-72-3 3-(4-Chloro-2-nitro-phenyl)-3-phenyl-pentan-2-one 
• 33484-96-7 3-Methyl-4-phenyl-hexanol-3 
• 104177-98-2 1-methyl-2-phenyl-butylamine 
• 34885-21-7 1,1-diphenyl-1-ethyl-propan-2-one 
• 609815-90-9 Trimethyl-((Z)-1-methyl-2-phenyl-but-1-enyloxy)-silane 
• 4564-82-3 erythro-3-phenylpentan-2-ol 
• 4564-82-3 threo-3-phenylpentan-2-ol 
• 103861-70-7 1-Phenyl-1-ethyl-propan-2-on-oxim 

Relevant articles and documents

Synthesis of 1-Alkyl-2-methylnaphthalenes from 3-Phenyl-2-alkanones

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Dynamic Reductive Kinetic Resolution of Benzyl Ketones using Alcohol Dehydrogenases and Anion Exchange Resins

Dynamic reductive kinetic resolutions of racemic 3-arylalkanones have been performed by the proper combination of an alcohol dehydrogenase and a basic anionic resin. The best results were found for the bioreduction with the alcohol dehydrogenase type A from Rhodococcus ruber DSM 44541 overexpressed in Escherichia coli (E. coli/ADH-A) and the commercially available evo-1.1.200, while the Amberlite IRA-440 C and the DOWEX-MWA-1 resins allowed efficient in situ racemizations. Reaction conditions were optimized in terms of enzyme source and loading, type and amount of resin, pH, temperature and reaction times, obtaining a series of (R,R)-substituted propan-2-ols with good conversions and both diastereoselectivity and stereoselectivity. As a proof of concept, the subsequent intramolecular cyclization of a selected propan-2-ol substrate afforded a valuable isochroman heterocycle without any loss of the optical purity.

Enzymatic kinetic resolution of racemic ketones catalyzed by Baeyer-Villiger monooxygenases

A set of racemic cyclic and linear ketones, as well as 2-phenylpropionaldehyde, were tested as substrates in the enzymatic Baeyer-Villiger oxidation catalyzed by two Baeyer-Villiger monooxygenases: phenylacetone monooxygenase (PAMO) and 4-hydroxyacetophenone monooxygenase (HAPMO). Excellent enantioselectivites (E > 200) can be obtained in the kinetic resolution processes depending on the substrate structure and the reaction conditions. The parameters affecting the biocatalytic properties of these enzymes were also studied, in order to establish a deeper understanding of these novel biocatalysts.