934-11-2

Basic information

• Product Name: (1-chloropropyl)benzene
• Synonyms: (1-chloropropyl)benzene;Benzene, (1-chloropropyl)-
• CAS NO: 934-11-2
• Molecular Formula: C₉H₁₁Cl
• Molecular Weight: 154.63664
• Mol File: 934-11-2.mol
• Article Data: 20

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (1-chloropropyl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: (1-chloropropyl)benzene(934-11-2)
• EPA Substance Registry System: (1-chloropropyl)benzene(934-11-2)

Safety Data

• Hazardous Substances Data: 934-11-2(Hazardous Substances Data)

Usage

General Description

"(1-Chloropropyl)benzene, also known as 1-Phenylpropyl chloride, is a chemical compound with the molecular formula C9H11Cl. It is an organic compound in the class of halogenated hydrocarbons. The compound is a colorless liquid and it is less dense than water. This means that it floats on water and is insoluble in it. This chemical is used in the production of other chemicals, including as an intermediate in the synthesis of pharmaceuticals. As it is a halogenated compound, it may cause burns and eye damage, hence appropriate safety practices should be adhered to while handling it. Its exposure also poses environmental hazards due to its non-biodegradable nature.

Upstream product

• 2114-36-5 1-bromopropylbenzene 
• 91968-53-5 1-phenylpropyl methoxymethyl ether 
• 52686-70-1 triethylamine-1-(2-naphthylethyl)borane 
• 75-05-8 acetonitrile 
• 103-65-1 phenylpropane 
• 637-50-3 1-phenylpropene 
• 108-90-7 chlorobenzene 
• 873-49-4 cyclopropylbenzene 
• 93-54-9 1-Phenyl-1-propanol 
• 122-04-3 4-nitro-benzoyl chloride 
• 93-55-0 1-phenyl-propan-1-one 

Downstream Products

• 37556-02-8 diethyl 2-(1-phenylpropyl)malonate 
• 637-50-3 1-phenylpropene 
• 39952-67-5 meso-3,4-diphenyl-hexane 
• 5789-31-1 rac-(hexane-3,4-diyl)dibenzene 
• 91968-37-5 2-(1'-phenylpropoxy)ethanol 
• 22906-19-0 (+)-Methyl-1-phenylpropylsulfid 
• 2845-27-4 3-phenylpentanoic acid 
• 15989-90-9 1,1-dichloro-3-phenylpent-1-ene 
• 54758-82-6 1-Phenoxy-4-(1-phenyl-propoxy)-benzene 
• 52030-31-6 2-methyl-8-(1-phenyl-propyl)-1-oxa-4,8-diaza-spiro[4.5]decan-3-one 
• 76877-93-5 1-mercapto-1-phenylpropane 
• 91970-83-1 Hydroxy-acetic acid 1-phenyl-propyl ester 
• 56484-56-1 2-<(α-Ethylbenzyl)thio>phenol 
• 1253851-96-5 (+/-)-tert-butyl(1-phenylpropyl)sulfane 

Relevant articles and documents

Nickel-Catalyzed Multicomponent Coupling: Synthesis of α-Chiral Ketones by Reductive Hydrocarbonylation of Alkenes

A nickel-catalyzed, multicomponent regio- and enantioselective coupling via sequential hydroformylation and carbonylation from readily available starting materials has been developed. This modular multicomponent hydrofunctionalization strategy enables the straightforward reductive hydrocarbonylation of a broad range of unactivated alkenes to produce a wide variety of unsymmetrical dialkyl ketones bearing a functionalized α-stereocenter, including enantioenriched chiral α-aryl ketones and α-amino ketones. It uses chiral bisoxazoline as a ligand, silane as a reductant, chloroformate as a safe CO source, and a racemic secondary benzyl chloride or an N-hydroxyphthalimide (NHP) ester of a protected α-amino acid as the alkylation reagent. The benign nature of this process renders this method suitable for late-stage functionalization of complex molecules.

Copper(I)-Catalyzed Enantioconvergent Borylation of Racemic Benzyl Chlorides Enabled by Quadrant-by-Quadrant Structure Modification of Chiral Bisphosphine Ligands

The first copper(I)-catalyzed enantioselective borylation of racemic benzyl chlorides has been realized by a quadrant-by-quadrant structure modulation of QuinoxP*-type bisphosphine ligands. This reaction converts racemic mixtures of secondary benzyl chlorides into the corresponding chiral benzylboronates with high enantioselectivity (up to 92 % ee). The results of mechanistic studies suggest the formation of a benzylic radical intermediate. The results of DFT calculations indicate that the optimal bisphosphine-copper(I) catalyst engages in noncovalent interactions that efficiently recognize the radical intermediate, and leads to high levels of enantioselectivity.

Preparation method of 1-chloropropyl benzene and derivative of 1-chloropropyl benzene

The invention provides a preparation method of 1-chloropropyl benzene and a derivative of 1-chloropropyl benzene, and belongs to the technical field of organic synthesis. The preparation method comprises the following steps: adding sulfoxide chloride into