152810-97-4

Upstream product

• 621-84-1 O-benzyl carbamate 
• 152810-89-4 4-Methylthioxanthydrol 
• 95-46-5 2-methylphenyl bromide 
• 147-93-3 Thiosalicylic acid 
• 87548-97-8 4-methylthioxanthone 
• 87548-96-7 2-(2'-Methylphenylthio)benzoic acid 

Relevant academic research and scientific papers

Synthesis of N-(9H-xanthen-9-yl)aminoalkanamide and N-(9H-thioxanthen-9-yl)aminoalkanamide derivatives and their in vitro evaluation as potential intercalators and antitumor drugs

A series of new N-(9H-xanthen-9-yl)aminoalkanamide and N-(9H-thioxanthen-9-yl)aminoalkanamide derivatives was synthesized and evaluated as potential intercalators by measuring their DNA binding affinity. They were also tested for cytotoxic activity against L1210. The results suggest that the cytotoxicity of these molecules was not due to an intercalating mechanism.

Synthesis and antitumor activity of some new 2-chloroethylnitrosoureas

The synthesis of a series of N-(2-chloroethyl)-N'-(9H-xanthen-9-yl)-N-nitrosoureas and N-(2-chloroethyl)-N'-(9H-thioxanthen-9-yl)-N-nitrosoureas is described. The title compounds were evaluated against NSCLCN6 L16 bronchial epidermoid carcinoma in vitro and some of them were found to be active. N-(2-chloroethyl)-N'-(2-methoxy-9H-xanthen-9-yl)-N-nitrosourea (8e) was active against leukemia P388 tumor system in mice.