87548-96-7

Basic information

• Product Name: Benzoic acid, 2-[(2-methylphenyl)thio]-
• Synonyms: 2-(2-methylthiophenoxy)benzoic acid;2-[(2-methylphenyl)thio]benzoic acid;HMS1443I22;2-carboxy-2'-methyldiphenyl sulfide
• CAS NO: 87548-96-7
• Molecular Formula: C14H12O2S
• Molecular Weight: 244.314
• Mol File: 87548-96-7.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 2-[(2-methylphenyl)thio]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 2-[(2-methylphenyl)thio]-(87548-96-7)
• EPA Substance Registry System: Benzoic acid, 2-[(2-methylphenyl)thio]-(87548-96-7)

Safety Data

• Hazardous Substances Data: 87548-96-7(Hazardous Substances Data)

Upstream product

• 137-06-4 2-thiocresol 
• 118-91-2 ortho-chlorobenzoic acid 
• 88-67-5 2-Iodobenzoic acid 
• 95-46-5 2-methylphenyl bromide 
• 147-93-3 Thiosalicylic acid 
• 615-37-2 ortho-methylphenyl iodide 

Downstream Products

• 107165-01-5 (2-(2-methylphenylthio)phenyl)ecetic acid 
• 132121-22-3 (2-o-Tolylsulfanyl-phenyl)-acetonitrile 
• 107165-04-8 6-Methyldibenzothiepin-10(11H)-one 
• 132121-08-5 C₁₄H₁₃ClS 
• 152810-97-4 N-(4-Methyl-9H-thioxanthen-9-yl) benzyl carbamate 
• 132121-21-2 2-(2-methylphenylthio)benzyl alcohol 
• 87548-97-8 4-methylthioxanthone 

Relevant articles and documents

Photobase generator

The object of the present invention is to provide a photobase generator capable of efficiently generating amines (tertiary amines and amidine) high in catalytic activity by sensing light with a wavelength of from 350 to 500 nm (especially, from 400 to 500 nm). The present invention is a photobase generator characterized in being represented by general formula (1) or (2). Y+ is a quaternary ammonio group of general formula (3) to (5), and X? is a counter anion selected from among a borate anion, a phenolate anion, and a carboxylate anion.

Synthesis and antitumor activity of some new 2-chloroethylnitrosoureas

The synthesis of a series of N-(2-chloroethyl)-N'-(9H-xanthen-9-yl)-N-nitrosoureas and N-(2-chloroethyl)-N'-(9H-thioxanthen-9-yl)-N-nitrosoureas is described. The title compounds were evaluated against NSCLCN6 L16 bronchial epidermoid carcinoma in vitro and some of them were found to be active. N-(2-chloroethyl)-N'-(2-methoxy-9H-xanthen-9-yl)-N-nitrosourea (8e) was active against leukemia P388 tumor system in mice.

TRICYCLIC NEUROLEPTICS: SYNTHESIS OF METABOLITES OF ISOFLOXYTHEPIN AND SOME RELATED COMPOUNDS

The isofloxythepin(I) metabolite IV was synthesized via the acids IX and XI and the esters X and XII.The enamine VIII was prepared from 3-fluoro-8-(2-propyl)dibenzothiepin-10(11H)-one by two methods and was reduced to I.Cloflumide (II) was obtained by reaction of 2,10-dichloro-7-fluoro-10,11-dihydrodibenzothiepin with 3-(1-piperazinyl)propionamide and was oxidized to the sulfoxide XVI.The unsaturated analogue XVII of clopithepin (III) was prepared from 2-chlorodibenzothiepin-10(11H)-one by reaction with 2-bromoethanol in the presence of 4-toluenesulfonic acid in boiling benzene and by the following substitution reaction with 2-(1-piperazinyl)ethanol.An improved synthesis of 6-methyldibenzothiepin-10(11H)-one (XIX) was elaborated.The acid XXVII was synthesized and cyclized with polyphosphate ester.A mixture of compounds was formed from which the ketone XXXVI was isolated and processed by reaction with formamide and formic acid at 200 deg C.One of the products was characterized as the formamide XXXIII and was reduced with lithium aluminium hydride to a basic product supposed to be XXXIV.A series of by-products was isolated and characterized.The enamine VIII (VUFB-17156) was found to be a strong neuroleptic agent, similar to isofloxythepin (I).The enol ether XVII (VUFB-17733) was characterized as a mild, practically noncataleptic neuroleptic agent.