152873-32-0

Upstream product

• 25152-20-9 5'-amino-5'-deoxythymidine 
• 385388-88-5 3'-isothiocyanato-5'-O-(4-methoxyphenyl)-diphenylmethyl-3'-deoxythymidine 
• 42926-80-7 5'-O-(4-monomethoxytrityl)-2'-deoxythymidine 
• 130945-07-2 3'-isothiocyanato-2',3'-dideoxythymidine 
• 152388-78-8 3'-azido-3'-deoxy-5'-O-monomethoxytritylthymidine 
• 124680-50-8 (1R,9R,10R)-10-[[(4-methoxyphenyl)diphenyl]methoxymethyl]-4-methyl-8,11-dioxa-2,6-diazatricyclo[7.2.1.0^2,7]dodeca-3,6-dien-5-one 
• 211300-21-9 3'-amino-5'-O-(4-methoxyphenyl)-diphenylmethyl-3'-deoxythymidine 
• 130446-03-6 methanesulfonic acid (2R,3S,5R)-2-[bis(4-methoxyphenyl)phenylmethoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)tetrahydrofuran-3-yl ester 
• 152873-31-9 N-(3'-deoxythymidin-3'-yl)-N'-(5'-deoxythymidin-5'-yl)thiourea 
• 14470-28-1 mono-4-methoxytrityl chloride 
• 50-89-5 thymidine 

Relevant academic research and scientific papers

Incorporation of positively charged deoxynucleic S-methylthiourea linkages into oligodeoxyribonucleotides

Oligodeoxyribonucleic acids (15- and 18-mers) containing both negatively charged phosphate and positively charged S-methyl thiourea internucleoside linkages (DNmt/DNA chimera) have been synthesized. DNA binding characteristics and nuclease resistance of DNmt/DNA chimera have been evaluated.

Synthesis, Enzymatic Stability and Base-pairing Properties of Oligothymidylates Containing Thymidine Dimers with Different N-Substituted Guanidine Linkages

Reaction of 5'-amino-5'deoxythymidine 1 with different S,S-dimethyl-N-substituted dithiocarbonimidates 2a-j afforded the N-substituted isothioureas 3a-j which, on further reaction with 3'-amino-3'-deoxythymidine 4 in the presence of AgNO3, led to thymidine dimers 5a-j with different N-substituted guanidine linkages.The dimer with a thiourea linkage (compound 9) was also prepared.Dimers 5a-h were incorporated at different positions in oligothymidylates by using phosphoramidite chemistry.Attempts to incorporate compounds 5i,j and 9 led to complex mixtures. 3'-Protected oligonucleotides showed somewhat higher stability to snake venom phosphodiesterase.Melting experiments revealed that the N-methylsulfonyl-substituted guanidine linkage best mimics the natural phosphodiester bridge.The fluorescence properties of oligonucleotides with dimer 5f were studied in view of its potential use as a non-radioactive label for DNA.