15291-78-8

Basic information

• Product Name: GINKGOLIDEM
• Synonyms: GINKGOLIDEM
• CAS NO: 15291-78-8
• Molecular Formula: C20H24O10
• Molecular Weight: 424.4
• Mol File: 15291-78-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 783.7 °C at 760 mmHg
• Flash Point: 282 °C
• Appearance: /
• Density: 1.63±0.1 g/cm3 (20 ºC 760 Torr)
• Refractive Index: 1.674
• PKA: 12.10±0.70(Predicted)
• CAS DataBase Reference: GINKGOLIDEM(CAS DataBase Reference)
• NIST Chemistry Reference: GINKGOLIDEM(15291-78-8)
• EPA Substance Registry System: GINKGOLIDEM(15291-78-8)

Safety Data

• Hazardous Substances Data: 15291-78-8(Hazardous Substances Data)

Usage

General Description

Ginkgolide B is a terpene trilactone compound found in the Ginkgo biloba tree, known for its potential therapeutic effects on neuroprotection, anti-inflammation, and anti-oxidation. It has been studied for its ability to protect against ischemic injury in the brain, reduce the progression of Alzheimer's disease, and improve cognitive function. Ginkgolide B is believed to achieve these effects by inhibiting platelet-activating factor (PAF) and downregulating inflammatory cytokines, as well as enhancing blood flow and oxygen delivery to the brain. Additionally, it has been investigated for its potential in treating asthma, allergies, and various cardiovascular diseases. Overall, ginkgolide B shows promise as a natural compound with neuroprotective and anti-inflammatory properties, making it a subject of interest for further research and potential therapeutic applications.

InChI:InChI=1/C20H24O10/c1-17(2,3)11-8(22)5-4-6(21)20-7-9(23)14(26)28-10(7)12(24)19(5,20)18(11)13(25)15(27)29-16(18)30-20/h5,7-13,16,22-25H,4H2,1-3H3/t5-,7+,8+,9+,10-,11+,12-,13+,16+,18?,19?,20+/m1/s1

Upstream product

• 882977-29-9 C₂₇H₂₈O₁₀ 
• 153355-66-9 7-Acetoxy-1-(tert-butyldiphenylsilyloxy)-3,10-dihydroxyginkgolid 
• 153355-67-0 7-Acetoxy-1-(tert-butyldiphenylsilyloxy)-10-hydroxy-3,14-didehydroginkgolid 
• 153481-63-1 1-(tert-butyldiphenylsilyloxy)-3,7,10-trihydroxyginkgolid 
• 153355-68-1 7-Acetoxy-1,10-dihydroxy-3,14-didehydroginkgolid 
• 15291-76-6 1,3,7,10-Tetrahydroxyginkgolid 
• 153382-67-3 7-Acetoxy-1,10-dihydroxy-14-epiginkgolid 
• 153541-09-4 1,7,10-Trihydroxy-14-epiginkgolid 

Relevant articles and documents

CORE-MODIFIED TERPENE TRILACTONES FROM GINKGO BILOBA EXTRACT AND BIOLOGICAL EVALUATION THEREOF

Lactone-rings of ginkgolides are converted into the corresponding tetrahydrofuran moieties via DIBAL-H reduction followed by deoxygenation of the formed lactols with Et3SiH/BF3Et2O producing a series of lactol-free ginkgol

Chemistry of the Ginkgolides, VI. - Preparation of 1,10-Dihydroxy- and 1,7,10-Trihydroxyginkgolide from 1,3,7,10-Tetrahydroxyginkgolide

1,3,7,10-Tetrahydroxyginkgolide ("ginkgolide C", 1) which can be isolated in large quantities from the terpene fraction of Ginkgo leaves, can be converted into 1-(tert-butyldiphenylsilyloxy)-3,7,10-trihydroxyginkgolide (2) in 95percent yield. 2 was conver