152918-47-3 Usage
Description
1-(6-Chloro-9H-purin-9-yl)-1-deoxy-N-methyl-2,3-O-isopropylidene-beta-D-ribofuranuronamide, commonly referred to as clade 9-CMP, is a complex chemical compound that features a purine base with a methyl group and a ribofuranuronamide moiety. It serves as a crucial intermediate in the synthesis of nucleoside analogs and their derivatives. 1-(6-Chloro-9H-purin-9-yl)-1-deoxy-N-methyl-2,3-O-isopropylidene-beta-D-ribofuranuronamide has garnered attention for its potential pharmaceutical applications, particularly in the realms of antiviral and anticancer drug development. Clade 9-CMP has shown biological activity in inhibiting viral replication and has demonstrated cytotoxic effects against cancer cells. Its distinctive structure and therapeutic potential render it a compelling subject for further exploration in medicinal chemistry.
Uses
Used in Pharmaceutical Industry:
1-(6-Chloro-9H-purin-9-yl)-1-deoxy-N-methyl-2,3-O-isopropylidene-beta-D-ribofuranuronamide is used as an intermediate in the synthesis of nucleoside analogs for its role in developing antiviral and anticancer drugs. Its ability to inhibit viral replication makes it a valuable component in the creation of new antiviral medications.
Used in Antiviral Applications:
In the field of virology, 1-(6-Chloro-9H-purin-9-yl)-1-deoxy-N-methyl-2,3-O-isopropylidene-beta-D-ribofuranuronamide is utilized as an antiviral agent due to its capacity to interfere with viral replication processes, thereby offering a potential treatment strategy for viral infections.
Used in Anticancer Applications:
Clade 9-CMP is employed as a cytotoxic agent in oncology, targeting and destroying cancer cells. Its potential to contribute to the development of anticancer drugs makes it a significant player in cancer research and treatment.
Used in Medicinal Chemistry Research:
1-(6-Chloro-9H-purin-9-yl)-1-deoxy-N-methyl-2,3-O-isopropylidene-beta-D-ribofuranuronamide is used as a subject of study in medicinal chemistry for its unique structure and the exploration of its therapeutic properties, paving the way for innovative drug discoveries.
Check Digit Verification of cas no
The CAS Registry Mumber 152918-47-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,2,9,1 and 8 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 152918-47:
(8*1)+(7*5)+(6*2)+(5*9)+(4*1)+(3*8)+(2*4)+(1*7)=143
143 % 10 = 3
So 152918-47-3 is a valid CAS Registry Number.
152918-47-3Relevant articles and documents
PROCESS FOR THE SYNTHESIS OF IB-MECA
-
, (2008/12/07)
The present disclosure provides a method for the synthesis of IB-MECA. More specifically, the present disclosure provides a simple and high yield method for Good Manufacturing Production (GMP) of IB-MECA. The method involves the reaction of 6-halopurine-9
N6-substituted N-alkyladenosine-5'-uronamides: bifunctional ligands having recognition groups for A1 and A2 adenosine receptors.
Olsson,Kusachi,Thompson,Ukena,Padgett,Daly
, p. 1683 - 1689 (2007/10/02)
The coronary vasoactivity of N-ethyl-1'-deoxy-1'-(6-amino-9H-purin-9-yl)-beta-D-ribofuranuronamide (NECA, 1) is over 2 orders of magnitude greater than that of adenosine, and the vasoactivity of certain N6-substituted adenosines is as much as 1 order of m