15296-49-8Relevant academic research and scientific papers
New series of isoniazid hydrazones linked with electron-withdrawing substituents
Vavrikova, Eva,Polanc, Slovenko,Kocevar, Marijan,Kosmrlj, Janez,Horvati, Kata,Bsze, Szilvia,Stolarikova, Jirina,Imramovsky, Ales,Vinsova, Jarmila
experimental part, p. 5902 - 5909 (2012/01/03)
A series of new isoniazid hydrazones was synthesized by two procedures. In the first isoniazid was activated with diethoxymethyl acetate and condensed with the appropriate anilines. Alternatively, substituted anilines were activated by diethoxymethyl acet
A facile protocol for the synthesis of mono-N-methyl anilines via formimidate intermediates
Sun, Nan,Wang, Shuai,Mo, Weimin,Hu, Baoxiang,Shen, Zhenlu,Hu, Xinquan
experimental part, p. 7142 - 7148 (2010/09/14)
A general procedure for the preparation of mono-N-methyl anilines has been developed with excellent yields. This protocol relies on a NaBH3(OAc) reduction of formimidate intermediates that are quantitatively generated by treatment of primary substituted anilines with triethyl orthoformate under the catalysis of MCM-41-SO3H mesoporous zeolite. The newly developed procedure was facile, efficient, and environmentally benign.
