152985-39-2Relevant academic research and scientific papers
Total synthesis and evaluation of the actin-binding properties of microcarpalide and a focused library of analogues
Fuerstner, Alois,Nagano, Takashi,Mueller, Christoph,Seidel, Guenter,Mueller, Oliver
, p. 1452 - 1462 (2008/02/04)
A comparative investigation shows that hydroxylated 10-membered lactones modeled around the fungal metabolites microcarpalide (1) and pinolidoxin (2) are endowed with selective actin-binding properties. Although less potent than the marine natural product
Stereoselective total synthesis and absolute configuration of the natural decanolides (-)-microcarpalide and (+)-lethaloxin. Identity of (+)-lethaloxin and (+)-pinolidoxin
Garcia-Fortanet, Jorge,Murga, Juan,Falomir, Eva,Carda, Miguel,Marco, J. Alberto
, p. 9822 - 9827 (2007/10/03)
Convergent, stereoselective syntheses of the pharmacologically active, naturally occurring lactones (-)-microcarpalide and (+)-lethaloxin have been achieved from the commercially available, chiral reagents (R)-glycidol, (S,S)-tartaric acid, and D-ribose a
Synthesis of (-)-pinolidoxin: Divergent synthetic strategy exploiting a common silacyclic precursor
Liu, Dong,Kozmin, Sergey A.
, p. 3005 - 3007 (2007/10/03)
(figure presented) We describe a highly convergent and efficient synthesis of (-)-pinolidoxin, a potent modulator of plant pathogenesis, providing unambiguous determination of the relative and absolute stereostructure of this highly oxygenated fungal meta
Total syntheses of the phytotoxic lactones herbarumin I and II and a synthesis-based solution of the pinolidoxin puzzle
Fuerstner, Alois,Radkowski, Karin,Wirtz, Conny,Goddard, Richard,Lehmann, Christian W.,Mynott, Richard
, p. 7061 - 7069 (2007/10/03)
A concise approach to a family of potent herbicidal 10-membered lactones is described on the basis of ring-closing metathesis (RCM) as the key step for the formation of the medium-sized ring. This includes the first total syntheses of herbarumin I (1) and
