152985-39-2Relevant articles and documents
Total synthesis and evaluation of the actin-binding properties of microcarpalide and a focused library of analogues
Fuerstner, Alois,Nagano, Takashi,Mueller, Christoph,Seidel, Guenter,Mueller, Oliver
, p. 1452 - 1462 (2008/02/04)
A comparative investigation shows that hydroxylated 10-membered lactones modeled around the fungal metabolites microcarpalide (1) and pinolidoxin (2) are endowed with selective actin-binding properties. Although less potent than the marine natural product
Synthesis of (-)-pinolidoxin: Divergent synthetic strategy exploiting a common silacyclic precursor
Liu, Dong,Kozmin, Sergey A.
, p. 3005 - 3007 (2007/10/03)
(figure presented) We describe a highly convergent and efficient synthesis of (-)-pinolidoxin, a potent modulator of plant pathogenesis, providing unambiguous determination of the relative and absolute stereostructure of this highly oxygenated fungal meta