152993-87-8Relevant academic research and scientific papers
Synthesis of some benzothiazoles by developing a new protocol using urea nitrate as a catalyst and their antimicrobial activities
Kumar, Parvin,Bhatia, Rimpy,Khanna, Radhika,Dalal, Aarti,Kumar, Dinesh,Surain, Parveen,Kamboj, Ramesh C.
, p. 585 - 596 (2017/10/05)
The present communication demonstrates the development of urea nitrate as an effective and efficient catalyst for the synthesis of some 2-substituted benzothiazoles. Instant progress of reaction at room temperature under solvent-free condition, very high catalytic activity, inexpensive, clean reaction profile, operational simplicity, large-scale synthesis and appreciable yields are the main advantages of this protocol. These synthesized benzothiazoles have been evaluated for their antibacterial and antifungal activities against Gram-positive bacterium (Bacillus subtilis MTCC 121); two Gram-negative bacteria (Escherichia coli MTCC 1652 and Pseudomonas aeruginosa MTCC 741) and two fungi (Candida albicans MTCC 3017 and Saccharomyces cerevisiae MTCC 170). Compound 3n was found the most active against all the tested microbes.
Cobalt-Catalyzed Decarboxylative C-H (Hetero)Arylation for the Synthesis of Arylheteroarenes and Unsymmetrical Biheteroaryls
Li, Yanrong,Qian, Fen,Wang, Mengshi,Lu, Hongjian,Li, Guigen
supporting information, p. 5589 - 5592 (2017/10/25)
A cobalt-catalyzed decarboxylative cross-coupling reaction of (hetero)aryl carboxylic acids with benzothiazoles or benzoxazoles is reported. This represents a first example of metal-catalyzed decarboxylative C-H heteroarylation of benzo-fused heterocycles. The transformation provides a convenient route, with good yields and functional group tolerance, to various important arylheteroaryl and unsymmetrical biheteroaryl structural motifs.
Pd(PPh3)4-catalyzed direct ortho-fluorination of 2-arylbenzothiazoles with an electrophilic fluoride N-fluorobenzenesulfonimide (NFSI)
Ding, Qiuping,Ye, Changqing,Pu, Shouzhi,Cao, Banpeng
, p. 409 - 416 (2014/01/06)
An efficient protocol was developed for regio-selective Pd-catalyzed direct ortho-fluorination of 2-arylbenzo[d]thiazoles using N-fluorobenzenesulfonimide (NFSI) as the F+ source, and l-proline as the crucial promoter. The present method offered a practical route to synthesize valuable fluorinated products, which are of potential importance in the pharmaceutical and agrochemical industries.
Magnetic nanoparticles-supported tungstosilicic acid: As an efficient magnetically separable solid acid for the synthesis of benzoazoles in water
Khalafi-Nezhad, Ali,Panahi, Farhad,Yousefi, Reza,Sarrafi, Sina,Gholamalipour, Yasaman
, p. 1311 - 1319 (2014/11/07)
The magnetic nanoparticles-supported tungstosilicic acid (TSAMNP) was found to be a highly efficient solid acid for the synthesis of benzoazoles in water. TSAMNP catalyst was achieved by the immobilization of tungstosilicic acid [H4(W12SiO40)] species on the silica core-shell magnetic nanoparticles (Fe3O4@SiO2). A variety of aldehydes were successfully condensed with 1,2-diaminobenzene, 2-aminophenol and 2-aminothiophenol in water as a green solvent to synthesize benzoazoles in good-to-excellent yields. TSAMNP catalyst was easily separated from the reaction mixture and reused several times without any loss of efficiency.
Pd-catalyzed decarboxylative arylation of thiazole benzoxazole, and polyfluorobenzene with substituted benzoic acids
Xie, Kai,Yang, Zhiyong,Zhou, Xingjian,Li, Xiujian,Wang, Sizhuo,Tan, Ze,An, Xiangyu,Guo, Can-Cheng
supporting information; experimental part, p. 1564 - 1567 (2010/06/16)
(Figure Represented) A Pd-catalyzed decarboxylative coupling of thiazoles and benzoxazole with various substituted benzoic acids Is developed. The reaction is compatible with both electron-rich and electron-poor benzoic acids. It can also be extended to the synthesis of polyfluoro-substituted biaryls using polyfluorobenzenes as the starting materials.
Methanesulfonic acid/SiO2 as an efficient combination for the synthesis of 2-substituted aromatic and aliphatic benzothiazoles from carboxylic acids
Sharghi, Hashem,Asemani, Omid
experimental part, p. 860 - 867 (2009/08/08)
Methanesulfonic acid/SiO2 (1 mL/0.3 g) was found to be as an expeditious mixture in the synthesis of 2-substituted aromatic and aliphatic benzothiazoles at 140° using carboxylic acids. After a simple workup, benzothiazoles were obtained in good yields. Simplicity, use of widely available and diverse carboxylic acids, and easy handling of the reaction conditions are among the benefits of the method. Copyright Taylor & Francis Group, LLC.
