15303-46-5

Basic information

• Product Name: 2-Isopropyl-5-oxohexanal
• Synonyms: 2-Isopropyl-5-oxohexanal
• CAS NO: 15303-46-5
• Molecular Formula: C₉H₁₆O₂
• Molecular Weight: 156.22
• Mol File: 15303-46-5.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Isopropyl-5-oxohexanal(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Isopropyl-5-oxohexanal(15303-46-5)
• EPA Substance Registry System: 2-Isopropyl-5-oxohexanal(15303-46-5)

Safety Data

• Hazardous Substances Data: 15303-46-5(Hazardous Substances Data)

Usage

Uses

5-Oxo-2-isopropylhexanal is an intermediate in the synthesis of β-Phellandrene (P294560), a terpene compound that can be found and extracted from the leaves of eucalyptus radiata. β-Phellandrene is also a major constituent of essential oils that have antiproliferative effects in human renal adenocarcinoma and amelanotic melanoma cells.

Upstream product

• 590-86-3 isovaleraldehyde 
• 78-94-4 methyl vinyl ketone 
• 55023-48-8 1-(3-methyl-but-1-enyl)-pyrrolidine 
• 51840-50-7 1-(3-methylbut-1-en-1-yl)piperidine 
• 78-93-3 butanone 

Downstream Products

• 2158-59-0 cryptone 
• 54868-48-3 (E)-5-isopropyl-8-methylnona-6,8-dien-2-one 
• 100295-52-1 (S)-(-)-4-isopropylcyclohex-2-enone 
• 2158-59-0 (R)-(-)-cryptone 

Relevant articles and documents

Direct 1,4-addition of aldehydes to vinylketones

Aldehydes directly add in 1,4-manner to vinylketones in the presence of 0.5 eq. of diethylaminotrimethylsilane without a solvent to give 5- ketoaldehydes.

Diethylamino(trimethyl)silane-mediated direct 1,4-addition of naked aldehydes to electron-deficient olefins

Diethylamino(trimethyl)silane-mediated direct 1,4-addition of naked aldehydes to electron-deficient olefins was discussed. Results showed that after the reaction the latent formyl groups were transformed back to aldehydes. Conjugated addition of aldehydes to electron-deficient olefins showed no successful precedents of direct 1,4-addition of naked aldehydes.

Stereoselective and Modular Assembly Method for Heterocycle-Fused Daucane Sesquiterpenoids

A stereoselective synthetic method is reported for the molecular framework found in common daucane and isodaucane sesquiterpenoid natural products. The synthetic method constitutes a scalable, modular, and also asymmetric access to a complex natural product scaffold, wherein the substitution pattern and the stereochemistry can be adjusted simply by choosing different starting materials. The method allows the rapid introduction of diverse heterocyclic substructures such as (benzo)furans, (benzo)thiophenes, dithiins, thiazoles, and indoles, which actually also facilitate and direct the key intramolecular annulation step.

Synthetic method of stealthy ketone (by machine translation)

The method disclosed by the invention is characterized in that the, method for synthesizing: the octrexone by the step of reacting synthetic enamine with tetrahydropyrrole and isovaleraldehyde; under 2 - 6h a basic condition of water to 2 - obtain a latent ketone crude; product comprises the following 2 - steps of: refluxing under, the alkaline condition, of water; and, distilling off the solvent, under reduced pressure, to obtain a latent ketone crude product . (by machine translation)

Diethylaminotrimethylsilane-catalyzed 1,4-addition of aldehydes to vinyl ketones: (3R)-3,7-dimethyl-2-(3-oxobutyl)-6-octenal: [(6-Octenal, 3,7-dimethyl-2-(3-oxobutyl)-, (3R)-)]

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