15303-46-5

Usage

Uses

Used in Pharmaceutical Industry:
2-Isopropyl-5-oxohexanal is used as an intermediate in the synthesis of β-Phellandrene (P294560), a terpene compound with potential antiproliferative effects. 2-Isopropyl-5-oxohexanal is particularly relevant in the development of treatments for human renal adenocarcinoma and amelanotic melanoma cells, as it may help inhibit tumor growth and progression.
Used in Aromatherapy and Essential Oils Industry:
2-Isopropyl-5-oxohexanal is used as a precursor for the production of β-Phellandrene, which is a major constituent of essential oils derived from various plants, including Eucalyptus radiata. These essential oils are widely used in aromatherapy for their potential therapeutic benefits, such as promoting relaxation, reducing inflammation, and supporting respiratory health.
Used in Chemical Synthesis:
2-Isopropyl-5-oxohexanal is used as a versatile building block in the synthesis of various chemical compounds, particularly within the terpene family. Its unique structure allows for further functionalization and modification, making it a valuable starting material for the development of new molecules with potential applications in various industries, such as agriculture, fragrances, and pharmaceuticals.

Upstream product

• 51840-50-7 1-(3-methylbut-1-en-1-yl)piperidine 
• 78-94-4 methyl vinyl ketone 
• 55023-48-8 1-(3-methyl-but-1-enyl)-pyrrolidine 
• 590-86-3 isovaleraldehyde 
• 78-93-3 butanone 

Downstream Products

• 2158-59-0 cryptone 
• 100295-52-1 (S)-(-)-4-isopropylcyclohex-2-enone 
• 2158-59-0 (R)-(-)-cryptone 
• 54868-48-3 (E)-5-isopropyl-8-methylnona-6,8-dien-2-one 

Relevant academic research and scientific papers

Direct 1,4-addition of aldehydes to vinylketones

Aldehydes directly add in 1,4-manner to vinylketones in the presence of 0.5 eq. of diethylaminotrimethylsilane without a solvent to give 5- ketoaldehydes.

Diethylamino(trimethyl)silane-mediated direct 1,4-addition of naked aldehydes to electron-deficient olefins

Diethylamino(trimethyl)silane-mediated direct 1,4-addition of naked aldehydes to electron-deficient olefins was discussed. Results showed that after the reaction the latent formyl groups were transformed back to aldehydes. Conjugated addition of aldehydes to electron-deficient olefins showed no successful precedents of direct 1,4-addition of naked aldehydes.

Catalytic enamine reaction: An expedient 1,4-conjugate addition of naked aldehydes to vinylketones and its application to synthesis of cyclohexenone from Stevia purpurea

Naked aldehydes directly add in a 1,4-manner to vinylketones in the presence of 0.2 equiv. of diethylamine in sealed tubes to provide 5-keto aldehydes.

Stereoselective and Modular Assembly Method for Heterocycle-Fused Daucane Sesquiterpenoids

A stereoselective synthetic method is reported for the molecular framework found in common daucane and isodaucane sesquiterpenoid natural products. The synthetic method constitutes a scalable, modular, and also asymmetric access to a complex natural product scaffold, wherein the substitution pattern and the stereochemistry can be adjusted simply by choosing different starting materials. The method allows the rapid introduction of diverse heterocyclic substructures such as (benzo)furans, (benzo)thiophenes, dithiins, thiazoles, and indoles, which actually also facilitate and direct the key intramolecular annulation step.

Synthetic method of stealthy ketone (by machine translation)

The method disclosed by the invention is characterized in that the, method for synthesizing: the octrexone by the step of reacting synthetic enamine with tetrahydropyrrole and isovaleraldehyde; under 2 - 6h a basic condition of water to 2 - obtain a latent ketone crude; product comprises the following 2 - steps of: refluxing under, the alkaline condition, of water; and, distilling off the solvent, under reduced pressure, to obtain a latent ketone crude product . (by machine translation)

Total synthesis of eudesmane terpenes: Cyclase phase

A full account of synthetic efforts toward dihydrojunenol, one of the lowest oxidized members of the eudesmane family of natural products, is presented. The final synthetic sequence illustrates a nine-step, gram-scale, enantioselective route to this bicyclic terpene with excellent stereocontrol and in 21% overall yield.