153052-89-2Relevant academic research and scientific papers
Synthesis of Met- and Leu-Enkephalin Analogues containing Chiral N,N'-Ethylene-bridged Phenylalanyl-Methionine and Leucine
Takenaka, Hiroshi,Miyake, Hiroyuki,Kojima, Yoshitane,Yasuda, Masahide,Gemba, Munekazu,Yamashita, Tetsushi
, p. 933 - 938 (2007/10/02)
Conformationally constrained N,N'-ethylene-bridged dipeptides (eXX') were conveniently synthesized in two steps using (R)- or (S)-phenylalanine (X = F) and -methionine (X'= M) as starting materials.These dipeptides are diastereoisomeric or enantiomeric, and were used as the carboxyl terminal residues of enkephalin analogues .The opiate activities of these pentapeptides were examined preliminarily by the mouse vas deferens assay, suggesting that these enkephalin analogues possess receptor-binding affinities.
