153186-25-5

Upstream product

• 116165-26-5 5-Methyl-1-trimethylsilanyl-1H-pyrimidine-2,4-dione 
• 153186-15-3 1,2-di-O-acetyl-3,5-di-O-benzyl-4-C-methyl-α-D-ribofuranose 
• 7288-28-0 2,4-bis(trimethylsiloxy)-5-methylpyrimidine 
• 65-71-4 thymin 
• 100-44-7 benzyl chloride 
• 63593-03-3 1,2-O-isopropylidene-3-O-benzyl-4-hydroxymethyl-α-D-ribofuranose 
• 149017-69-6 (3aR,5R,6S,6aR)-6-(benzyloxy)-5-(benzyloxymethyl)-2,2,5-trimethyltetrahydrofuro[2,3-d][1,3]dioxole 
• 153186-14-2 3,5-di-O-benzyl-4-C-iodomethyl-1,2-O-isopropylidene-α-D-ribofuranose 
• 153186-10-8 ((3aR,5R,6S,6aR)-6-(benzyloxy)-5-((benzyloxy)methyl)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)methanol 

Downstream Products

• 160766-56-3 3',5'-di-O-benzyl-4'-C-methylthymidine 

Relevant academic research and scientific papers

Synthesis and biological evaluation of 4'-C-methyl nucleosides

A series of 2'-deoxy, 2',3'-unsaturated and 2',3'-dideoxynucleoside analogues, which have an additional methyl group at the 4'-position, have been synthesized. When evaluated for their inhibitory activity against HIV in MT-4 cell, 2'-deoxy-4'-C-methyl nucleosides exhibited potent activity.

Synthesis of 4'-C-methylnucleosides.

Several 4'-C-methylnucleosides were prepared. 1H-NMR studies on these nucleotides showed that they have the 3'-exo furanose ring conformation different from the 3'-endo conformation of natural nucleosides.