153186-29-9

Usage

Uses

Used in Pharmaceutical Industry:
4'-C-Methylcytidine is used as a potential therapeutic agent for the development of antiviral drugs. Its ability to regulate gene expression and its involvement in various biological processes, such as viral infections and the immune response, make it a promising candidate for the treatment of viral diseases.
Used in Research and Development:
4'-C-Methylcytidine is used as a target for further research and drug development due to its significant effects on the structure and function of RNA molecules. Understanding the role of this chemical modification in RNA biology can lead to the discovery of new therapeutic strategies and the development of novel antiviral drugs.
Used in Diagnostic Applications:
4'-C-Methylcytidine can be used as a biomarker for the detection and monitoring of viral infections. The presence of this modified nucleoside in RNA molecules may indicate an active viral infection, providing valuable information for diagnosis and treatment planning.
Used in Gene Regulation Studies:
4'-C-Methylcytidine is used as a tool in gene regulation studies to investigate the mechanisms by which this modification influences gene expression. Understanding the role of 4'-C-Methylcytidine in gene regulation can provide insights into the development of new therapeutic approaches for various diseases and conditions.

Upstream product

• 153186-26-6 1-(4-C-methyl-β-D-ribofuranosyl)-uracil 
• 503543-47-3 1-(4-C-methyl-β-D-ribofuranosyl)4-thio-uracil 
• 794517-49-0 N⁴-benzoyl-2,3,5-tri-O-acetyl-4'-C-methylcytidine 
• 153186-27-7 2',3',5'-tri-O-acetyl-4'-C-methyluridine 
• 153186-15-3 1,2-di-O-acetyl-3,5-di-O-benzyl-4-C-methyl-α-D-ribofuranose 
• 153186-14-2 3,5-di-O-benzyl-4-C-iodomethyl-1,2-O-isopropylidene-α-D-ribofuranose 
• 149017-69-6 (3aR,5R,6S,6aR)-6-(benzyloxy)-5-(benzyloxymethyl)-2,2,5-trimethyltetrahydrofuro[2,3-d][1,3]dioxole 
• 63593-03-3 1,2-O-isopropylidene-3-O-benzyl-4-hydroxymethyl-α-D-ribofuranose 
• 503543-45-1 1-(5-O-benzoyl-4-C-methyl-2,3-O-acetyl-β-D-ribofuranosyl)uracil 
• 153186-28-8 1-(2,3,5-tri-O-acetyl-4-C-methyl-β-D-ribofuranosyl)-4-(1,2,4-triazol-1-yl)-1H-pyrimidine-2-one 
• 153186-10-8 ((3aR,5R,6S,6aR)-6-(benzyloxy)-5-((benzyloxy)methyl)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)methanol 
• 153186-24-4 2'-O-acetyl-3',5'-di-O-benzyl-4'-C-methyluridine 

Relevant academic research and scientific papers

Methods and compositions for treating flaviviruses and pestiviruses using 4'-modified nucleoside

A method and composition for treating a host infected with flavivirus or pestivirus comprising administering an effective flavivirus or pestivirus treatment amount of a described 4′-modified nucleoside or a pharmaceutically acceptable salt or prodrug thereof, is provided.

Methods and compositions for treating hepatitis C virus using 4'-modified nucleosides

A compound, method and composition for treating a host infected with a hepatitis C viral comprising administering an effective hepatitis C treatment amount of a described 4′-disubstituted nucleoside or a pharmaceutically acceptable salt or prodrug thereof, is provided.

Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase

The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-d

4′-C-methyl-β-D-ribofuranosyl purine and pyrimidine nucleosides revisited

In order to evaluate their antiviral properties, a series of 4′-C-methyl-β-D-ribofuranosyl purine and pyrimidine nucleosides has been prepared. Unfortunately, none of these 4′-branched nucleosides showed any antiviral activity or cytotoxcity when tested a

Synthesis of 4'-C-methylnucleosides.

Several 4'-C-methylnucleosides were prepared. 1H-NMR studies on these nucleotides showed that they have the 3'-exo furanose ring conformation different from the 3'-endo conformation of natural nucleosides.