1533-04-6

Basic information

• Product Name: 2-PHENYL-3'-TRIFLUOROMETHYLACETOPHENONE
• Synonyms: 2-(2-quinolyl)quinoline;2-PHENYL-3'-TRIFLUOROMETHYLACETOPHENONE
• CAS NO: 1533-04-6
• Molecular Formula: C₁₅H₁₁F₃O
• Molecular Weight: 264.24
• Mol File: 1533-04-6.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 315.4°C at 760 mmHg
• Flash Point: 165.7°C
• Appearance: /
• Density: 1.228g/cm³
• Vapor Pressure: 0.00044mmHg at 25°C
• Refractive Index: 1.523
• CAS DataBase Reference: 2-PHENYL-3'-TRIFLUOROMETHYLACETOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PHENYL-3'-TRIFLUOROMETHYLACETOPHENONE(1533-04-6)
• EPA Substance Registry System: 2-PHENYL-3'-TRIFLUOROMETHYLACETOPHENONE(1533-04-6)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 1533-04-6(Hazardous Substances Data)

Usage

General Description

2-PHENYL-3'-TRIFLUOROMETHYLACETOPHENONE is a chemical compound with the molecular formula C16H11F3O. It is classified as an acetophenone, which is a class of organic compounds used in the production of various pharmaceuticals, fragrances, and other chemicals. This particular acetophenone is characterized by a phenyl group and a trifluoromethyl group attached to a central ketone functional group. It is used in the synthesis of various pharmaceuticals and agrochemicals due to its versatile reactivity and functional groups. Additionally, it may also be used as a building block in the preparation of other organic compounds and as a research tool in the study of organic chemistry and drug development.

InChI:InChI=1/C15H11F3O/c16-15(17,18)13-8-4-7-12(10-13)14(19)9-11-5-2-1-3-6-11/h1-8,10H,9H2

Upstream product

• 368-77-4 3-trifluoromethylbenzonitrile 
• 6921-34-2 benzylmagnesium chloride 
• 454-92-2 3-(trifluoromethyl)benzoic acid 
• 108-86-1 bromobenzene 
• 349-76-8 3'-(trifluoromethyl)acetophenone 
• 454-87-5 3-(trifluoromethyl)benzenediazonium tetrafluoroborate 
• 4747-15-3 1-(2-methoxyvinyl)benzene 
• 100-52-7 benzaldehyde 
• 103-82-2 phenylacetic acid 
• 100-39-0 benzyl bromide 
• 2251-65-2 3-(Trifluoromethyl)benzoyl chloride 
• 126309-76-0 1-(2-phenylethynyl)-3-(trifluoromethyl)benzene 
• 2557-13-3 3-trifluoromethylbenzoic acid methyl ester 
• 62673-31-8 benzyl(bromo)zinc 

Downstream Products

• 132227-13-5 1,3-dihydro-3-<2-(3-trifluoromethylphenyl)-2-(1-phenyl-3-oxopyrazol-3-ylimino)ethylidene>indol-2(H)-one 
• 132227-14-6 2-phenyl-5-(3-trifluoromethylphenyl)-11H-pyrazolo<3',4':2,3>azepino-<4,5-b>indol-1(2H)-one 
• 132227-11-3 1,3-dihydro-3-<2-(3-trifluoromethylphenyl)-2-oxoethylidene>indol-2(H)-one 
• 132227-16-8 1,3-dihydro-3-hydroxy-3-<2-(3-trifluoromethylphenyl)-2'-oxoethyl>indol-2(H)-one 
• 40103-85-3 1-(3-(trifluoromethyl)phenyl)-2-phenylethane-1,2-dione 

Relevant articles and documents

Selective α-Methylation of Aryl Ketones Using Quaternary Ammonium Salts as Solid Methylating Agents

We describe the use of phenyl trimethylammonium iodide (PhMe3NI) as an alternative methylating agent for introducing a CH3group in α-position to a carbonyl group. Compared to conventional methylating agents, quaternary ammonium salts have the advantages of being nonvolatile, noncancerogenic, and easy-to-handle solids. This regioselective method is characterized by ease of operational setup, use of anisole as green solvent, and yields up to 85%.

Ring size and nothing else matters: unusual regioselectivity of alkyne hydration by NHC gold(i) complexes

We have investigated the role of ring sizes and substituents in NHC ligands in some (NHC)Au(i) complexes in the hydration of internal alkynes. Despite the fact that using (NHC)Au(i) complexes in the hydration of diarylacetylenes leads to Markovnikov-type products, the precise tuning of ligands allows changing the regioselectivity in arylalkylacetylene hydration to the anti-Markovnikov-type.

Catalytic decarboxylative cross-ketonisation of aryl- and alkylcarboxylic acids using iron catalysts

In the presence of catalytic amounts of magnetite nanopowder, mixtures of aromatic and aliphatic carboxylic acids are converted selectively into the corresponding aryl alkyl ketones. As by-products, only carbon dioxide and water are released. This catalytic cross-ketonisation allows the regioselective acylation of aromatic systems and, thus, represents a sustainable alternative to Friedel-Crafts acylations.